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    CG14777 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31099, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14777provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026872
    Locus tag
    Dmel_CG14777
    See related
    AllianceGenome:FB:FBgn0026872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH63812; Dmel\CG14777; EG:80H7.10
    Summary
    Predicted to enable monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head. Orthologous to human MPV17L (MPV17 mitochondrial inner membrane protein like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14777 in Genome Data Viewer
    Location:
    2A4-2A4; 1-0.2 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1466134..1468692)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1360167..1362725)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nucleostemin 3 Neighboring gene O-fucosyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pickel

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila model of the neurological symptoms in Mpv17-related diseases. Kodani A, et al. Sci Rep, 2022 Dec 31. PMID 36587049, Free PMC Article
    2. A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Kaplan DD, et al. Genes Dev, 2008 Jul 15. PMID 18628395, Free PMC Article
    3. Drosophila Mpv17 forms an ion channel and regulates energy metabolism. Corrà S, et al. iScience, 2023 Oct 20. PMID 37810222, Free PMC Article
    4. Characterization of gene expression regulated by human OTK18 using Drosophila melanogaster as a model system for innate immunity. Spresser CR, et al. J Genet, 2008 Aug. PMID 18776638
    5. Zinc Detoxification: A Functional Genomics and Transcriptomics Analysis in Drosophila melanogaster Cultured Cells. Mohr SE, et al. G3 (Bethesda), 2018 Feb 2. PMID 29223976, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14777-PB
    CG14777-PC
    CG14777-PD
    CG14777-PE
    CG14777-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1466134..1468692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297853.1 → NP_001284782.1  uncharacterized protein Dmel_CG14777, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284782.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W588, Q9XZT2
      Conserved Domains (1) summary
      pfam04117
      Location:118 → 181
      Mpv17_PMP22; Mpv17 / PMP22 family

    2. NM_130561.3 → NP_569917.1  uncharacterized protein Dmel_CG14777, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569917.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W588, Q9XZT2
      Related
      FBpp0070243
      Conserved Domains (1) summary
      pfam04117
      Location:118 → 181
      Mpv17_PMP22; Mpv17 / PMP22 family

    3. NM_001297852.1 → NP_001284781.1  uncharacterized protein Dmel_CG14777, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284781.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W588, Q9XZT2
      Conserved Domains (1) summary
      pfam04117
      Location:118 → 181
      Mpv17_PMP22; Mpv17 / PMP22 family

    4. NM_001297851.1 → NP_001284780.1  uncharacterized protein Dmel_CG14777, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284780.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W588, Q9XZT2
      Conserved Domains (1) summary
      pfam04117
      Location:118 → 181
      Mpv17_PMP22; Mpv17 / PMP22 family

    5. NM_001169163.1 → NP_001162634.1  uncharacterized protein Dmel_CG14777, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162634.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W588, Q9XZT2
      Conserved Domains (1) summary
      pfam04117
      Location:118 → 181
      Mpv17_PMP22; Mpv17 / PMP22 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W588 Q9W588
    Q9XZT2 Q9XZT2

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