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    rsh radish [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32253, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rshprovided by FlyBase
    Official Full Name
    radishprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265597
    Locus tag
    Dmel_CG44424
    See related
    AllianceGenome:FB:FBgn0265597
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15720; CG18646; CG42628; CG42629; CG4346; CG4368; CG44424; Dmel\CG44424; FBpp0073550; R5_X:12971309..12973132; rad; Rad; Rsh
    Old locus tag
    Dmel_CG15720; Dmel_CG18646; Dmel_CG42628; Dmel_CG42629; Dmel_CG4346
    Summary
    Predicted to enable GTPase activator activity. Involved in anesthesia-resistant memory and regulation of heart contraction. Located in several cellular components, including axon; neuronal cell body; and nucleus. Is expressed in synaptic neuropil domain and synaptic neuropil subdomain. Used to study alcohol use disorder. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rsh in Genome Data Viewer
    Location:
    11D6-11D10; 1-41 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12988615..13079070)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12882648..12973103)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44840 Neighboring gene uncharacterized protein Neighboring gene mir-971 stem loop Neighboring gene hemipterous Neighboring gene licorne

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Social facilitation of long-lasting memory retrieval in Drosophila. Chabaud MA, et al. Curr Biol, 2009 Oct 13. PMID 19781943
    2. Vision in Flies: Measuring the Attention Span. Koenig S, et al. PLoS One, 2016. PMID 26848852, Free PMC Article
    3. The radish gene reveals a memory component with variable temporal properties. LaFerriere H, et al. PLoS One, 2011. PMID 21912703, Free PMC Article
    4. Interplay between metabolic energy regulation and memory pathways in Drosophila. Sgammeglia N, et al. Trends Neurosci, 2022 Jul. PMID 35597687
    5. Memory mechanisms. A common cascade for long-term memory. Goda Y. Curr Biol, 1995 Feb 1. PMID 7743176

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • mir-971-RA; Dmel\mir-971-RA; CR42929-RA; Dmel\CR42929-RA
    • mir-971-RB; Dmel\mir-971-RB; CR42929-RB; Dmel\CR42929-RB

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in anesthesia-resistant memory IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anesthesia-resistant memory TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in olfactory learning TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    radish
    Names
    CG44424-PI
    CG44424-PJ
    CG44424-PK
    CG44424-PL
    CG44424-PM
    CG44424-PN
    rsh-PI
    rsh-PJ
    rsh-PK
    rsh-PL
    rsh-PM
    rsh-PN

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12988615..13079070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298248.1 → NP_001285177.1  radish, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285177.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JJU0
      Conserved Domains (5) summary
      smart00225
      Location:1442 → 1501
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:1519 → 1621
      BACK; BTB And C-terminal Kelch
      cd08368
      Location:560 → 600
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam02145
      Location:870 → 1051
      Rap_GAP; Rap/ran-GAP
      cl02518
      Location:1439 → 1498
      BTB; BTB/POZ domain

    2. NM_001298250.1 → NP_001285179.1  radish, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285179.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JF15
      Conserved Domains (5) summary
      smart00225
      Location:1298 → 1357
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:1375 → 1477
      BACK; BTB And C-terminal Kelch
      cd08368
      Location:560 → 600
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam02145
      Location:870 → 1051
      Rap_GAP; Rap/ran-GAP
      cl02518
      Location:1295 → 1354
      BTB; BTB/POZ domain

    3. NM_001298247.1 → NP_001285176.1  radish, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285176.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JDH0
      Conserved Domains (6) summary
      PHA03309
      Location:207 → 539
      PHA03309; transcriptional regulator ICP4; Provisional
      smart00225
      Location:1467 → 1526
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd08368
      Location:583 → 623
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam02145
      Location:893 → 1074
      Rap_GAP; Rap/ran-GAP
      cl28903
      Location:1531 → 1603
      BACK; BACK (BTB and C-terminal Kelch) domain
      cl38908
      Location:1289 → 1344
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    4. NM_001298251.1 → NP_001285180.1  radish, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285180.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JBI1
      Conserved Domains (5) summary
      smart00225
      Location:1321 → 1380
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:1398 → 1500
      BACK; BTB And C-terminal Kelch
      cd08368
      Location:583 → 623
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam02145
      Location:893 → 1074
      Rap_GAP; Rap/ran-GAP
      cl02518
      Location:1318 → 1377
      BTB; BTB/POZ domain

    5. NM_001298249.1 → NP_001285178.1  radish, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285178.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JEQ0
      Conserved Domains (5) summary
      smart00225
      Location:1319 → 1378
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:1396 → 1498
      BACK; BTB And C-terminal Kelch
      cd08368
      Location:583 → 623
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam02145
      Location:893 → 1074
      Rap_GAP; Rap/ran-GAP
      cl02518
      Location:1316 → 1375
      BTB; BTB/POZ domain

    6. NM_132622.4 → NP_572850.5  radish, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572850.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7S4
      Conserved Domains (4) summary
      smart00225
      Location:833 → 898
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:916 → 1018
      BACK; BTB And C-terminal Kelch
      pfam02145
      Location:265 → 446
      Rap_GAP; Rap/ran-GAP
      cl02518
      Location:836 → 895
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I7S4 Q9I7S4
    X2JBI1 X2JBI1
    X2JDH0 X2JDH0
    X2JEQ0 X2JEQ0
    X2JF15 X2JF15
    X2JJU0 X2JJU0

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