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    Cngl Cyclic nucleotide-gated ion channel-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32468, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cnglprovided by FlyBase
    Official Full Name
    Cyclic nucleotide-gated ion channel-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263257
    Locus tag
    Dmel_CG43395
    See related
    AllianceGenome:FB:FBgn0263257
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18210; CG43395; CG9176; cngl; CNGL; dmCNG3; Dmel\CG43395; mdcds_55060
    Old locus tag
    Dmel_CG18210; Dmel_CG9176
    Summary
    Predicted to enable intracellularly cyclic nucleotide-activated monoatomic cation channel activity. Predicted to be involved in monoatomic cation transport. Predicted to be located in membrane. Predicted to be part of intracellular cyclic nucleotide activated cation channel complex. Is expressed in several structures, including adult brain cell body rind; adult mushroom body; adult optic lobe; organism subdivision; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cngl in Genome Data Viewer
    Location:
    13C1-13C1; 1-50 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15386038..15441252, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15280071..15335285, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene abnormal chemosensory jump 6 Neighboring gene Protein phosphatase 1 at 13C Neighboring gene uncharacterized protein Neighboring gene scamp Neighboring gene Adenosylhomocysteinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a putative cyclic nucleotide-gated channel from Drosophila melanogaster. Miyazu M, et al. Insect Mol Biol, 2000 Jun. PMID 10886412
    2. Knockdown of a Cyclic Nucleotide-Gated Ion Channel Impairs Locomotor Activity and Recovery From Hypoxia in Adult Drosophila melanogaster. Qiu S, et al. Front Physiol, 2022. PMID 35530504, Free PMC Article
    3. PKA and cAMP/CNG Channels Independently Regulate the Cholinergic Ca(2+)-Response of Drosophila Mushroom Body Neurons. Pavot P, et al. eNeuro, 2015 Mar-Apr. PMID 26464971, Free PMC Article
    4. Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases. Vermehren-Schmaedick A, et al. Genetics, 2010 Sep. PMID 20592263, Free PMC Article
    5. Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade. Dijkers PF, et al. Mol Biol Cell, 2009 Sep. PMID 19625446, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: c15423429-15421974 mobile_element_type = transposon:pogo{}CG18210[pogo139]
    • Loc: c15433640-15433220 mobile_element_type = transposon:INE-1{}3523

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of intracellular cyclic nucleotide activated cation channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyclic nucleotide-gated ion channel-like
    Names
    CG43395-PD
    CG43395-PE
    CG43395-PF
    CG43395-PI
    CG43395-PJ
    CG43395-PK
    CNG channel-like
    Cngl-PD
    Cngl-PE
    Cngl-PF
    Cngl-PI
    Cngl-PJ
    Cngl-PK
    cng-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15386038..15441252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258761.3 → NP_001245690.1  cyclic nucleotide-gated ion channel-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245690.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NGG3
      Conserved Domains (4) summary
      COG0664
      Location:535 → 665
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:541 → 653
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:245 → 466
      Ion_trans; Ion transport protein
      pfam07885
      Location:367 → 461
      Ion_trans_2; Ion channel

    2. NM_001258762.3 → NP_001245691.1  cyclic nucleotide-gated ion channel-like, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245691.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEI3
      Conserved Domains (4) summary
      COG0664
      Location:550 → 680
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:556 → 668
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:260 → 481
      Ion_trans; Ion transport protein
      pfam07885
      Location:382 → 476
      Ion_trans_2; Ion channel

    3. NM_167441.5 → NP_727848.3  cyclic nucleotide-gated ion channel-like, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727848.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXV8
      Conserved Domains (3) summary
      COG0664
      Location:578 → 708
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:584 → 696
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:260 → 509
      Ion_trans; Ion transport protein

    4. NM_001370020.1 → NP_001356908.1  cyclic nucleotide-gated ion channel-like, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A499NPJ3
      Conserved Domains (2) summary
      cd00038
      Location:556 → 668
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:240 → 481
      Ion_trans; Ion transport protein

    5. NM_001272642.2 → NP_001259571.2  cyclic nucleotide-gated ion channel-like, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259571.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PH69
      Conserved Domains (4) summary
      COG0664
      Location:550 → 680
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:556 → 668
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:260 → 481
      Ion_trans; Ion transport protein
      pfam07885
      Location:382 → 476
      Ion_trans_2; Ion channel

    6. NM_132794.5 → NP_573022.2  cyclic nucleotide-gated ion channel-like, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573022.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YTY7, Q9VXV7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A499NPJ3 A0A499NPJ3
    M9NEI3 M9NEI3
    M9NGG3 M9NGG3
    M9PH69 M9PH69
    Q9U5E2 Q9U5E2
    Q9VXV7 Q9VXV7
    Q9VXV8 Q9VXV8

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