ctrip circadian trip [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ctripprovided by FlyBase
Official Full Name: circadian tripprovided by FlyBase
Primary source: FLYBASE:FBgn0260794
Locus tag: Dmel_CG42574
See related: AllianceGenome:FB:FBgn0260794
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14656; CG17735; CG42574; Ctrip; CTRIP; CTRIP/TRIP12; Dmel\CG42574; TRIP12
Old locus tag: Dmel_CG14656; Dmel_CG17735
Summary: Predicted to enable ubiquitin protein ligase activity. Involved in positive regulation of circadian rhythm and positive regulation of protein catabolic process. Predicted to be located in nucleus. Predicted to be active in nuclear speck. Is expressed in several structures, including adult head and neurosecretory neurons. Human ortholog(s) of this gene implicated in Clark-Baraitser syndrome. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 82D5-82D6; 3-47.1 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (4786284..4812096, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (612006..637818, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identify a clock function for the circadian trip gene, which encodes a HECT-domain E3 ubiquitin ligase.
Title: The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0545 (e-PCR)
- UniSTS:35270

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: circadian trip

Names: CG42574-PA; CG42574-PB; CG42574-PC; CG42574-PE; CG42574-PF; CG42574-PH; CG42574-PI; CG42574-PJ; CG42574-PK; CG42574-PL; CG42574-PM; ctrip-PA; ctrip-PB; ctrip-PC; ctrip-PE; ctrip-PF; ctrip-PH; ctrip-PI; ctrip-PJ; ctrip-PK; ctrip-PL; ctrip-PM

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

4786284..4812096 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202243.3 → NP_001189172.2 circadian trip, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189172.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JD62, F6M9W1

Conserved Domains (3) summary

smart00678
Location:1005 → 1077

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

pfam15814
Location:1581 → 1671

FAM199X; Protein family FAM199X

cl00077
Location:2414 → 2734

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
NM_001300233.1 → NP_001287162.1 circadian trip, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287162.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGQ5, F6M9W2

Conserved Domains (3) summary

smart00678
Location:1170 → 1242

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

pfam15814
Location:1746 → 1836

FAM199X; Protein family FAM199X

cl00077
Location:2579 → 2899

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
NM_001202246.3 → NP_001189175.2 circadian trip, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189175.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JCW5, F6M9W2

Conserved Domains (3) summary

smart00678
Location:1198 → 1270

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

pfam15814
Location:1774 → 1864

FAM199X; Protein family FAM199X

cl00077
Location:2607 → 2927

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
NM_001300234.1 → NP_001287163.1 circadian trip, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287163.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LHQ4, F6M9W1

Conserved Domains (3) summary

smart00678
Location:977 → 1049

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

COG5064
Location:655 → 880

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

cl27008
Location:2386 → 2706

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
NM_001202247.2 → NP_001189176.1 circadian trip, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189176.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JDB5, F6M9W1

Conserved Domains (3) summary

smart00678
Location:1006 → 1078

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

pfam15814
Location:1582 → 1672

FAM199X; Protein family FAM199X

cl00077
Location:2415 → 2735

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
NM_001202244.2 → NP_001189173.1 circadian trip, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189173.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JCV6, F6M9W2

Conserved Domains (3) summary

smart00678
Location:1199 → 1271

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

pfam15814
Location:1775 → 1865

FAM199X; Protein family FAM199X

cl00077
Location:2608 → 2928

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
NM_001202241.2 → NP_001189170.1 circadian trip, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189170.1

Status: REVIEWED

UniProtKB/TrEMBL

F6M9W0, Q9VN58

Conserved Domains (4) summary

smart00678
Location:1409 → 1481

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

pfam04554
Location:688 → 731

Extensin_2; Extensin-like region

pfam15814
Location:1985 → 2074

FAM199X; Protein family FAM199X

cl00077
Location:2818 → 3138

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
NM_001202242.2 → NP_001189171.1 circadian trip, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189171.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JDB5, F6M9W1

Conserved Domains (3) summary

smart00678
Location:1006 → 1078

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

pfam15814
Location:1582 → 1672

FAM199X; Protein family FAM199X

cl00077
Location:2415 → 2735

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
NM_001300232.1 → NP_001287161.1 circadian trip, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287161.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGR2, F6M9W0

Conserved Domains (4) summary

smart00678
Location:1380 → 1452

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

pfam04554
Location:688 → 731

Extensin_2; Extensin-like region

pfam15814
Location:1956 → 2045

FAM199X; Protein family FAM199X

cl00077
Location:2789 → 3109

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
NM_001202245.3 → NP_001189174.1 circadian trip, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189174.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JDA1, F6M9W0

Conserved Domains (4) summary

smart00678
Location:1408 → 1480

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

pfam04554
Location:688 → 731

Extensin_2; Extensin-like region

pfam15814
Location:1984 → 2073

FAM199X; Protein family FAM199X

cl00077
Location:2817 → 3137

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
NM_141239.5 → NP_649496.3 circadian trip, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649496.3

Status: REVIEWED

UniProtKB/TrEMBL

F6M9W0, Q9VN58

Conserved Domains (4) summary

smart00678
Location:1409 → 1481

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

pfam04554
Location:688 → 731

Extensin_2; Extensin-like region

pfam15814
Location:1985 → 2074

FAM199X; Protein family FAM199X

cl00077
Location:2818 → 3138

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4JCV6		A0A0B4JCV6
A0A0B4JCW5		A0A0B4JCW5
A0A0B4JD62		A0A0B4JD62
A0A0B4JDA1		A0A0B4JDA1
A0A0B4JDB5		A0A0B4JDB5
A0A0B4LGQ5		A0A0B4LGQ5
A0A0B4LGR2		A0A0B4LGR2
A0A0B4LHQ4		A0A0B4LHQ4
Q9VN58		Q9VN58