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    puml pummelig [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35733, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pumlprovided by FlyBase
    Official Full Name
    pummeligprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033226
    Locus tag
    Dmel_CG1882
    See related
    AllianceGenome:FB:FBgn0033226
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    5; ABHD4; CG1882; CGI-58; DmABHD4; Dmel\CG1882; EPHX2; Pummelig
    Summary
    Enables carboxylesterase activity and phospholipase activity. Involved in lipid storage. Located in lipid droplet; mitochondrion; and peroxisome. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval fat body; embryonic/larval midgut primordium; and mesoderm. Used to study obesity. Human ortholog(s) of this gene implicated in Chanarin-Dorfman syndrome; autosomal recessive congenital ichthyosis 1; and colon adenocarcinoma. Orthologous to several human genes including ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See puml in Genome Data Viewer
    Location:
    43E18-43E18; 2-57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7812504..7815486)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3700009..3702991)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene saxophone Neighboring gene Tubulin tyrosine ligase-like 12 Neighboring gene cathepsin D Neighboring gene uncharacterized protein Neighboring gene Proteasome alpha1 subunit Neighboring gene photorepair

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The α/β-hydrolase domain-containing 4- and 5-related phospholipase Pummelig controls energy storage in Drosophila. Hehlert P, et al. J Lipid Res, 2019 Aug. PMID 31164391, Free PMC Article
    2. Evolutionary origins of the endocannabinoid system. McPartland JM, et al. Gene, 2006 Mar 29. PMID 16434153
    3. The contribution of the Drosophila model to lipid droplet research. Kühnlein RP. Prog Lipid Res, 2011 Oct. PMID 21620889
    4. Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster α-Esterase-7. Birner-Gruenberger R, et al. Insect Biochem Mol Biol, 2012 Mar. PMID 22198472
    5. Proteogenomics of Adenosine-to-Inosine RNA Editing in the Fruit Fly. Kuznetsova KG, et al. J Proteome Res, 2018 Nov 2. PMID 30298734

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these results show that the ABHD4/5 family member Puml is a versatile phospholipase that regulates Drosophila body fat storage and energy metabolism.
      Title: The α/β-hydrolase domain-containing 4- and 5-related phospholipase Pummelig controls energy storage in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pummelig
    Names
    CG1882-PA
    CG1882-PB
    CG1882-PC
    CG1882-PD
    CG1882-PE
    CG1882-PF
    CG1882-PG
    abhydrolase 1
    puml-PA
    puml-PB
    puml-PC
    puml-PD
    puml-PE
    puml-PF
    puml-PG
    NP_001286168.1
    NP_001286169.1
    NP_001286170.1
    NP_610326.1
    NP_724609.1
    NP_724610.1
    NP_724611.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7812504..7815486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299241.1 → NP_001286170.1  pummelig, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286170.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U191
      Conserved Domains (2) summary
      COG0596
      Location:114 → 382
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:114 → 226
      Abhydrolase_5; Alpha/beta hydrolase family

    2. NM_136482.2 → NP_610326.1  pummelig, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610326.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U191
      Related
      FBpp0087910
      Conserved Domains (2) summary
      COG0596
      Location:114 → 382
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:114 → 226
      Abhydrolase_5; Alpha/beta hydrolase family

    3. NM_165562.2 → NP_724611.1  pummelig, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724611.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQU9
      Related
      FBpp0087912
      Conserved Domains (1) summary
      PLN02894
      Location:4 → 320
      PLN02894; hydrolase, alpha/beta fold family protein

    4. NM_165561.2 → NP_724610.1  pummelig, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724610.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQU9
      Related
      FBpp0087911
      Conserved Domains (1) summary
      PLN02894
      Location:4 → 320
      PLN02894; hydrolase, alpha/beta fold family protein

    5. NM_001299240.1 → NP_001286169.1  pummelig, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286169.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U191
      Conserved Domains (2) summary
      COG0596
      Location:114 → 382
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:114 → 226
      Abhydrolase_5; Alpha/beta hydrolase family

    6. NM_001299239.1 → NP_001286168.1  pummelig, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286168.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQU9
      Conserved Domains (1) summary
      PLN02894
      Location:4 → 320
      PLN02894; hydrolase, alpha/beta fold family protein

    7. NM_165560.2 → NP_724609.1  pummelig, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQU9
      Related
      FBpp0087913
      Conserved Domains (1) summary
      PLN02894
      Location:4 → 320
      PLN02894; hydrolase, alpha/beta fold family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U191 Q5U191
    Q7JQU9 Q7JQU9

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