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    CG14744 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35858, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14744provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033324
    Locus tag
    Dmel_CG14744
    See related
    AllianceGenome:FB:FBgn0033324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14744
    Summary
    Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in mitochondrial calcium ion homeostasis and monoatomic cation transport. Predicted to be located in mitochondrial crista. Predicted to be active in membrane. Orthologous to human SLC8B1 (solute carrier family 8 member B1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14744 in Genome Data Viewer
    Location:
    44E2-44E2; 2-59 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8706388..8709486, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4593893..4596991, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Peptidoglycan recognition protein SC1a Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Negative regulation by amidase PGRPs shapes the Drosophila antibacterial response and protects the fly from innocuous infection. Paredes JC, et al. Immunity, 2011 Nov 23. PMID 22118526
    2. Glial solute carrier transporters in Drosophila and mice. Featherstone DE. Glia, 2011 Sep. PMID 21732427
    3. Function-informed transcriptome analysis of Drosophila renal tubule. Wang J, et al. Genome Biol, 2004. PMID 15345053, Free PMC Article
    4. A Drosophila protein-interaction map centered on cell-cycle regulators. Stanyon CA, et al. Genome Biol, 2004. PMID 15575970, Free PMC Article
    5. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium:sodium antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monoatomic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial crista ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14744-PC
    CG14744-PD
    CG14744-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8706388..8709486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299278.1 → NP_001286207.1  uncharacterized protein Dmel_CG14744, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEV7
      Conserved Domains (1) summary
      pfam01699
      Location:79 → 221
      Na_Ca_ex; Sodium/calcium exchanger protein

    2. NM_001103762.3 → NP_001097232.2  uncharacterized protein Dmel_CG14744, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097232.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7I1
      Conserved Domains (1) summary
      pfam01699
      Location:450 → 601
      Na_Ca_ex; Sodium/calcium exchanger protein

    3. NM_001299279.1 → NP_001286208.1  uncharacterized protein Dmel_CG14744, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286208.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEG9
      Conserved Domains (1) summary
      pfam01699
      Location:79 → 221
      Na_Ca_ex; Sodium/calcium exchanger protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LEG9 A0A0B4LEG9
    A0A0B4LEV7 A0A0B4LEV7
    A1Z7I1 A1Z7I1

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