Sting sting [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Stingprovided by FlyBase
Official Full Name: stingprovided by FlyBase
Primary source: FLYBASE:FBgn0033453
Locus tag: Dmel_CG1667
See related: AllianceGenome:FB:FBgn0033453
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1667; Dmel\CG1667; dmSTING; dSting; dSTING; STING
Summary: Enables 2',3'-cyclic GMP-AMP binding activity; 3',2'-cyclic GMP-AMP binding activity; and cyclic-di-GMP binding activity. Involved in several processes, including positive regulation of defense response; response to bacterium; and response to virus. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 46B4-46B4; 2-61 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9842686..9845512)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5730191..5733017)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Viral infection disrupts intestinal homeostasis via Sting-dependent NF-kappaB signaling in Drosophila.
Title: Viral infection disrupts intestinal homeostasis via Sting-dependent NF-κB signaling in Drosophila.
Drosophila melanogaster Sting mediates Coxiella burnetii infection by reducing accumulation of reactive oxygen species.
Title: Drosophila melanogaster Sting mediates Coxiella burnetii infection by reducing accumulation of reactive oxygen species.
RNF144A promotes antiviral responses by modulating STING ubiquitination.
Title: RNF144A promotes antiviral responses by modulating STING ubiquitination.
Drosophila STING protein has a role in lipid metabolism.
Title: Drosophila STING protein has a role in lipid metabolism.
2'3'-cGAMP triggers a STING- and NF-kappaB-dependent broad antiviral response in Drosophila.
Title: 2'3'-cGAMP triggers a STING- and NF-κB-dependent broad antiviral response in Drosophila.
The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models.
Title: The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models.
STING is an evolutionarily conserved antimicrobial effector between flies and mammals.
Title: Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 2',3'-cyclic GMP-AMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables 2',3'-cyclic GMP-AMP binding	IDA Inferred from Direct Assay more info	PubMed
enables 3',2'-cyclic GMP-AMP binding	IDA Inferred from Direct Assay more info	PubMed
enables 3',2'-cyclic GMP-AMP binding	ISS Inferred from Sequence or Structural Similarity more info
enables cyclic-di-GMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclic-di-GMP binding	IDA Inferred from Direct Assay more info	PubMed
enables cyclic-di-GMP binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in antibacterial innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antiviral innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGAS/STING signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cGAS/STING signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of antimicrobial peptide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macroautophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type I interferon production	IEA Inferred from Electronic Annotation more info
involved_in response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed