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    Ddr Discoidin domain receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3346209, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ddrprovided by FlyBase
    Official Full Name
    Discoidin domain receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053531
    Locus tag
    Dmel_CG33531
    See related
    AllianceGenome:FB:FBgn0053531
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11573; CG13985; CG33531; CG9488; CG9490; CT33540; ddr; DDR; Dmel\CG33531
    Old locus tag
    CG13984; Dmel_CG13984
    Summary
    Predicted to enable collagen binding activity and protein tyrosine kinase collagen receptor activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of neuron projection development; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including alcoholic liver cirrhosis; bone disease (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and skin melanoma. Orthologous to several human genes including DDR1 (discoidin domain receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ddr in Genome Data Viewer
    Location:
    26C1-26C2; 2-19 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6253123..6323466)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6253123..6323466)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44823 Neighboring gene UDP-glycosyltransferase family 37 member B1 Neighboring gene Arylalkylamine N-acetyltransferase-like 2 Neighboring gene long non-coding RNA:CR46410 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PDZ domain-containing guanine nucleotide exchange factor Neighboring gene Pez

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differentiation signals from glia are fine-tuned to set neuronal numbers during development. Prasad AR, et al. Elife, 2022 Sep 12. PMID 36094172, Free PMC Article
    2. Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway. Lee JH, et al. Mol Cell Biol, 2002 Nov. PMID 12370312, Free PMC Article
    3. Discoidin domain receptor regulates ensheathment, survival and caliber of peripheral axons. Corty MM, et al. Development, 2022 Dec 1. PMID 36355066, Free PMC Article
    4. Cross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy. Min Y, et al. Nat Commun, 2023 Nov 2. PMID 37919278, Free PMC Article
    5. The Batten disease gene CLN3 is required for the response to oxidative stress. Tuxworth RI, et al. Hum Mol Genet, 2011 May 15. PMID 21372148, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase collagen receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    discoidin domain receptor
    Names
    CG33531-PD
    CG33531-PF
    CG33531-PG
    Ddr-PD
    Ddr-PF
    Ddr-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6253123..6323466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298737.1 → NP_001285666.1  discoidin domain receptor, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285666.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59DZ7
      Conserved Domains (4) summary
      smart00219
      Location:759 → 1038
      TyrKc; Tyrosine kinase, catalytic domain
      smart00231
      Location:106 → 262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:109 → 261
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd05051
      Location:753 → 1040
      PTKc_DDR; Catalytic domain of the Protein Tyrosine Kinases, Discoidin Domain Receptors

    2. NM_001014474.4 → NP_001014474.3  discoidin domain receptor, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014474.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59DZ7
      Conserved Domains (4) summary
      smart00219
      Location:759 → 1038
      TyrKc; Tyrosine kinase, catalytic domain
      smart00231
      Location:106 → 262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:109 → 261
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd05051
      Location:753 → 1040
      PTKc_DDR; Catalytic domain of the Protein Tyrosine Kinases, Discoidin Domain Receptors

    3. NM_001169424.2 → NP_001162895.2  discoidin domain receptor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162895.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHA2, G2J650
      Conserved Domains (2) summary
      smart00231
      Location:106 → 262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:109 → 261
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHA2 E1JHA2
    Q59DZ7 Q59DZ7

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