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    CG6675 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35439, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6675provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032973
    Locus tag
    Dmel_CG6675
    See related
    AllianceGenome:FB:FBgn0032973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6675
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6675 in Genome Data Viewer
    Location:
    40E3-40E3; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22108964..22110449)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22108964..22110449)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46480 Neighboring gene uncharacterized protein Neighboring gene Cyclin K

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome features of innate immune memory in Drosophila. Fuse N, et al. PLoS Genet, 2022 Oct. PMID 36252180, Free PMC Article
    2. Effect of Low Doses (5-40 cGy) of Gamma-irradiation on Lifespan and Stress-related Genes Expression Profile in Drosophila melanogaster. Zhikrevetskaya S, et al. PLoS One, 2015. PMID 26248317, Free PMC Article
    3. The disease-associated proteins Drosophila Nab2 and Ataxin-2 interact with shared RNAs and coregulate neuronal morphology. Rounds JC, et al. Genetics, 2022 Jan 4. PMID 34791182, Free PMC Article
    4. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341
    5. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. Pal S, et al. J Biol Chem, 2007 Mar 23. PMID 17227774

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6675-PB
    CG6675-PC
    NP_001286130.1
    NP_610132.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      22108964..22110449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136288.2 → NP_610132.3  uncharacterized protein Dmel_CG6675, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610132.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9A0N1, Q6IDD7, Q9V9P0
      Conserved Domains (1) summary
      cd00707
      Location:116 → 381
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

    2. NM_001299201.1 → NP_001286130.1  uncharacterized protein Dmel_CG6675, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286130.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9A0N1, X2J9D7
      Conserved Domains (1) summary
      cd00707
      Location:112 → 377
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V9P0 Q9V9P0
    X2J9D7 X2J9D7

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