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    Argk1 Arginine kinase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39041, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Argk1provided by FlyBase
    Official Full Name
    Arginine kinase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0000116
    Locus tag
    Dmel_CG32031
    See related
    AllianceGenome:FB:FBgn0000116
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AK; AK-1; AK1; argk; argK; Argk; ArgK; ARK; CG32031; CG4929; CG5173; Dmel\CG32031; KARG
    Summary
    Predicted to enable arginine kinase activity and creatine kinase activity. Predicted to be involved in phosphorylation. Located in cytosol; extracellular region; and plasma membrane. Is expressed in several structures, including adult head; adult heart; brain; follicle cell; and larval muscle cell. Orthologous to several human genes including CKMT1A (creatine kinase, mitochondrial 1A); CKMT1B (creatine kinase, mitochondrial 1B); and CKMT2 (creatine kinase, mitochondrial 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Argk1 in Genome Data Viewer
    Location:
    66F3-66F4; 3-28 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9048781..9066027, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9041881..9059127, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Dorsocross1 Neighboring gene Arginine kinase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of arginine kinase within the genus Drosophila. Collier GE. J Hered, 1990 May-Jun. PMID 2166106
    2. Cytoplasmic and mitochondrial arginine kinases in Drosophila: evidence for a single gene. Munneke LR, et al. Biochem Genet, 1988 Feb. PMID 2837172
    3. Re-evaluation of the structure and physiological function of guanidino kinases in fruitfly (Drosophila), sea urchin (Psammechinus miliaris) and man. Wyss M, et al. Biochem J, 1995 Jul 1. PMID 7619066, Free PMC Article
    4. Noninvasive measurement of gene expression in skeletal muscle. Walter G, et al. Proc Natl Acad Sci U S A, 2000 May 9. PMID 10805778, Free PMC Article
    5. Mitochondrial phosphagen kinases support the volatile power demands of motor nerve terminals. Justs KA, et al. J Physiol, 2023 Dec. PMID 37942946, Free PMC Article

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arginine kinase interacts with 2MIT and is involved in Drosophila melanogaster short-term memory.
      Title: Arginine kinase interacts with 2MIT and is involved in Drosophila melanogaster short-term memory.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables arginine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables creatine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables creatine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphocreatine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in extracellular region HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    arginine kinase 1
    Names
    Argk1-PA
    Argk1-PB
    Argk1-PC
    Argk1-PD
    Argk1-PE
    Argk1-PG
    Argk1-PH
    CG32031-PA
    CG32031-PB
    CG32031-PC
    CG32031-PD
    CG32031-PE
    CG32031-PG
    CG32031-PH
    arginine kinase
    insect intestinal mucin iim22
    NP_001097555.1
    NP_001097556.2
    NP_001286989.1
    NP_523988.2
    NP_729446.1
    NP_729447.1
    NP_729448.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9048781..9066027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300060.1 → NP_001286989.1  arginine kinase 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286989.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48610, Q8IQB9, Q8IQC0, Q8T0S2, Q9VST5, Q9VST6
      UniProtKB/TrEMBL
      A8JNP1
      Conserved Domains (1) summary
      cd07932
      Location:9 → 356
      arginine_kinase_like; Phosphagen (guanidino) kinases such as arginine kinase and similar enzymes

    2. NM_168312.3 → NP_729447.1  arginine kinase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729447.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48610
      Related
      FBpp0076271
      Conserved Domains (1) summary
      cd07932
      Location:85 → 432
      arginine_kinase_like; Phosphagen (guanidino) kinases such as arginine kinase and similar enzymes

    3. NM_168313.4 → NP_729448.1  arginine kinase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729448.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48610
      Related
      FBpp0076273
      Conserved Domains (1) summary
      cd07932
      Location:49 → 396
      arginine_kinase_like; Phosphagen (guanidino) kinases such as arginine kinase and similar enzymes

    4. NM_001104085.2 → NP_001097555.1  arginine kinase 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097555.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNP2
      Conserved Domains (1) summary
      cd07932
      Location:28 → 375
      arginine_kinase_like; Phosphagen (guanidino) kinases such as arginine kinase and similar enzymes

    5. NM_168311.3 → NP_729446.1  arginine kinase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729446.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48610
      Related
      FBpp0076270
      Conserved Domains (1) summary
      cd07932
      Location:215 → 562
      arginine_kinase_like; Phosphagen (guanidino) kinases such as arginine kinase and similar enzymes

    6. NM_079264.3 → NP_523988.2  arginine kinase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523988.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48610, Q8IQB9, Q8IQC0, Q8T0S2, Q9VST5, Q9VST6
      UniProtKB/TrEMBL
      A8JNP1
      Related
      FBpp0076272
      Conserved Domains (1) summary
      cd07932
      Location:9 → 356
      arginine_kinase_like; Phosphagen (guanidino) kinases such as arginine kinase and similar enzymes

    7. NM_001104086.2 → NP_001097556.2  arginine kinase 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097556.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48610, Q8IQB9, Q8IQC0, Q8T0S2, Q9VST5, Q9VST6
      UniProtKB/TrEMBL
      A8JNP1
      Conserved Domains (1) summary
      cd07932
      Location:9 → 356
      arginine_kinase_like; Phosphagen (guanidino) kinases such as arginine kinase and similar enzymes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNP1 A8JNP1
    A8JNP2 A8JNP2
    P48610.2 P48610

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