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    Art2a ADP-ribosyltransferase 2a [ Mus musculus (house mouse) ]

    Gene ID: 11871, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Art2aprovided by MGI
    Official Full Name
    ADP-ribosyltransferase 2aprovided by MGI
    Primary source
    MGI:MGI:107546
    See related
    Ensembl:ENSMUSG00000092517 AllianceGenome:MGI:107546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rt6; Rt-6; ARTC2; Ly92a; Rt6-1; Art2a-ps
    Summary
    Enables NAD+-protein-arginine ADP-ribosyltransferase activity and hydrolase activity, acting on glycosyl bonds. Involved in NAD catabolic process. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Biased expression in large intestine adult (RPKM 1.5), spleen adult (RPKM 0.9) and 9 other tissues See more
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    Genomic context

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    See Art2a in Genome Data Viewer
    Location:
    7 E2; 7 54.6 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101201657..101210072, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101552453..101560865, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 2A, cGMP-stimulated Neighboring gene microRNA 139 Neighboring gene predicted gene, 35363 Neighboring gene STARR-positive B cell enhancer ABC_E6576 Neighboring gene STARR-seq mESC enhancer starr_19694 Neighboring gene predicted gene, 19765 Neighboring gene ribosomal protein L6 pseudogene Neighboring gene ADP-ribosyltransferase 2b Neighboring gene predicted gene, 45995

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nucleotide and deduced amino acid sequence for the mouse homologue of the rat T-cell differentiation marker RT6. Koch F, et al. Nucleic Acids Res, 1990 Jun 25. PMID 2362814, Free PMC Article
    2. Defects in the structure and expression of the genes for the T cell marker Rt6 in NZW and (NZB x NZW)F1 mice. Koch-Nolte F, et al. Int Immunol, 1995 May. PMID 7547715
    3. Mouse T-cell antigen rt6.1 has thiol-dependent NAD glycohydrolase activity. Hara N, et al. J Biochem, 2000 Oct. PMID 11011142
    4. Mouse Rt6.1 is a thiol-dependent arginine-specific ADP-ribosyltransferase. Hara N, et al. Eur J Biochem, 1999 Jan. PMID 9914505
    5. Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice. Ohlrogge W, et al. Mol Cell Biol, 2002 Nov. PMID 12370300, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NAD induces calcium elevation and astrocyte death by an ART2 and P2X7-mediated mechanism.
      Title: NAD induces astrocyte calcium flux and cell death by ART2 and P2X7 pathway.
    2. Extracellular nicotinamide adenine dinucleotide (NAD) acts via ART2.1 to regulate P2X7 purinergic receptor-dependent inflammatory responses in murine macrophages.
      Title: Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells.
    3. identify ART2.1 as a new candidate for linking autocrine/paracrine activation of inflammatory macrophages to the release of NAD, a critical intracellular metabolite
      Title: Lipopolysaccharide, IFN-gamma, and IFN-beta induce expression of the thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in murine macrophages.
    4. Transfer of a genetically disrupted CD38 allele into the autoimmune diabetes-prone NOD/Lt background accelerated diabetes onset in both sexes, whereas transfer of a disrupted ART2a/b complex had no effect.
      Title: Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.
    5. ART2a is required for ADP-ribosylation of cell surface proteins
      Title: Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice.
    6. CD38 controls the level of cell surface protein ADP-ribosylation by limiting the substrate availability for ART2.
      Title: CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein-arginine ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on glycosyl bonds IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-cell ecto-ADP-ribosyltransferase 1
    Names
    ADP-ribosyltransferase 2a, pseudogene
    ADP-ribosyltransferase C2 and C3 toxin-like 2
    NAD(+) glycohydrolase
    T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 1
    T-cell differentiation marker Rt6 homolog 1
    T-cell mono(ADP-ribosyl)transferase 1
    mono(ADP-ribosyl)transferase 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007490.1 → NP_031516.1  T-cell ecto-ADP-ribosyltransferase 1 precursor

      See identical proteins and their annotated locations for NP_031516.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, coding) encodes the functional protein. This variant is found in BALB/c mice but not in C57BL/6J mice.
      Source sequence(s)
      X52991
      UniProtKB/Swiss-Prot
      O35278, P17981, Q0VB79, Q64173
      Conserved Domains (1) summary
      pfam01129
      Location:27 → 242
      ART; NAD:arginine ADP-ribosyltransferase

    RNA

    1. NR_033804.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, non-coding) is represented as non-coding because the use of the 5'-most supported translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This transcript is found in C57BL/6J mice but not in BALB/c mice.
      Source sequence(s)
      AC129609, AK018555
      Related
      ENSMUST00000173420.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101201657..101210072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17981.2 GenPept UniProtKB/Swiss-Prot:P17981

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