Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp3a13provided by MGI
Official Full Name: cytochrome P450, family 3, subfamily a, polypeptide 13provided by MGI
Primary source: MGI:MGI:88610
See related: Ensembl:ENSMUSG00000029727 AllianceGenome:MGI:88610
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IIIAm2
Summary: Predicted to enable several functions, including caffeine oxidase activity; iron ion binding activity; and monooxygenase activity. Acts upstream of or within positive regulation of gene expression. Predicted to be located in cytoplasm. Is expressed in several structures, including heart; liver; lung; metanephros; and spleen. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A7 (cytochrome P450 family 3 subfamily A member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 14.5), small intestine adult (RPKM 11.6) and 5 other tissues See more
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Genomic context

Location:: 5 G2; 5 76.89 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137891195..137923872, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137892933..137925610, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A significant increase of Cyp3a13 transcript level and protein expression was found in the liver and hippocampi during spontaneous recurrent seizures in mice.
Title: Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures.
CYP3A13 occurs naturally in aortic tissue.
Title: Mouse aortic muscle cells respond to oxygen following cytochrome P450 3A13 gene transfer.
Oxygen acts primarily through the complex CYP3A13 (sensor)/endothelin-1 (effector) and, in an accessory way, directly onto endothelin-1. However, even without CYP3A13, the ductus arteriosus may close postnatally thanks to the contribution of ET-1.
Title: Cytochrome P-450 3A13 and endothelin jointly mediate ductus arteriosus constriction to oxygen in mice.
Genomic structure and regulation of CYP3a13.
Title: Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Markers

Cyp3a13 (e-PCR), detects polymorphism
- UniSTS:463003

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables caffeine oxidase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables estrogen 16-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables estrogen 2-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables retinoic acid 4-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables steroid binding	ISO Inferred from Sequence Orthology more info
enables steroid hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables testosterone 6-beta-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables testosterone 6-beta-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables vitamin D 24-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables vitamin D3 25-hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in oxidative demethylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 3A13

Names: CYPIIIA13; cytochrome P450, steroid inducible 3a13

NP_031845.1

EC 1.14.14.1

XP_030109981.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007819.4 → NP_031845.1 cytochrome P450 3A13

See identical proteins and their annotated locations for NP_031845.1

Status: VALIDATED

Source sequence(s)

AK136494, AK149572

Consensus CDS

CCDS19781.1

UniProtKB/Swiss-Prot

Q64464

UniProtKB/TrEMBL

Q3UW87

Related

ENSMUSP00000031741.8, ENSMUST00000031741.8

Conserved Domains (1) summary

cd20650
Location:67 → 492

CYP3A; cytochrome P450 family 3, subfamily A

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

137891195..137923872 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254121.2 → XP_030109981.1 cytochrome P450 3A13 isoform X1

UniProtKB/Swiss-Prot

Q64464

UniProtKB/TrEMBL

Q3UW87

Conserved Domains (1) summary

cd20650
Location:67 → 492

CYP3A; cytochrome P450 family 3, subfamily A