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    Trip13 thyroid hormone receptor interactor 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292206, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trip13provided by RGD
    Official Full Name
    thyroid hormone receptor interactor 13provided by RGD
    Primary source
    RGD:1308516
    See related
    EnsemblRapid:ENSRNOG00000015810 AllianceGenome:RGD:1308516
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including double-strand break repair; meiosis I; and negative regulation of nuclear division. Predicted to act upstream of or within germ cell development and meiosis I. Predicted to be located in male germ cell nucleus. Predicted to be active in chromosome and nucleus. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome 3. Orthologous to human TRIP13 (thyroid hormone receptor interactor 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 60.3), Spleen (RPKM 40.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Trip13 in Genome Data Viewer
    Location:
    1p11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (31185700..31230638)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (29357093..29402078)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (31967980..32012923)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene tubulin polymerization promoting protein Neighboring gene zinc finger, DHHC-type containing 11 Neighboring gene uncharacterized LOC134484978 Neighboring gene bromodomain containing 9 Neighboring gene small nucleolar RNA SNORA21 Neighboring gene NKD inhibitor of WNT signaling pathway 2 Neighboring gene solute carrier family 12 member 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within female meiosis I ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within male meiosis I ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in meiotic recombination checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle assembly checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within oocyte maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reciprocal meiotic recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synaptonemal complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptonemal complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pachytene checkpoint protein 2 homolog
    Names
    TR-interacting protein 13
    TRIP-13
    thyroid receptor-interacting protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011930.1NP_001011930.1  pachytene checkpoint protein 2 homolog

      See identical proteins and their annotated locations for NP_001011930.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083900
      UniProtKB/Swiss-Prot
      Q5XHZ9
      UniProtKB/TrEMBL
      A0A8L2R3S2, A6JUW1
      Related
      ENSRNOP00000021532.3, ENSRNOT00000021532.6
      Conserved Domains (1) summary
      cd19508
      Location:121319
      RecA-like_Pch2-like; ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      31185700..31230638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103353.2XP_038959281.1  pachytene checkpoint protein 2 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5XHZ9
      UniProtKB/TrEMBL
      A0A8L2R3S2, A6JUW1
      Conserved Domains (1) summary
      cd19508
      Location:121319
      RecA-like_Pch2-like; ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains
    2. XM_008758681.3XP_008756903.1  pachytene checkpoint protein 2 homolog isoform X1

      See identical proteins and their annotated locations for XP_008756903.1

      UniProtKB/Swiss-Prot
      Q5XHZ9
      UniProtKB/TrEMBL
      A0A8L2R3S2, A6JUW1
      Conserved Domains (1) summary
      cd19508
      Location:121319
      RecA-like_Pch2-like; ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains