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    Bco2 beta-carotene oxygenase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315644, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bco2provided by RGD
    Official Full Name
    beta-carotene oxygenase 2provided by RGD
    Primary source
    RGD:1309022
    See related
    EnsemblRapid:ENSRNOG00000038746 AllianceGenome:RGD:1309022
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bcdo2; Ab2-079
    Summary
    Predicted to enable beta,beta-carotene-9',10'-cleaving oxygenase activity; beta-carotene 15,15'-dioxygenase activity; and carotenoid dioxygenase activity. Predicted to be involved in isoprenoid metabolic process; regulation of mitochondrial membrane potential; and regulation of reactive oxygen species metabolic process. Predicted to act upstream of or within xanthophyll metabolic process. Predicted to be located in ribosome. Predicted to be active in mitochondrion. Orthologous to human BCO2 (beta-carotene oxygenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 141.8), Liver (RPKM 106.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bco2 in Genome Data Viewer
    Location:
    8q23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (59778571..59803597, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (50882174..50907676, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (54965577..54990604, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene placenta expressed transcript 1 Neighboring gene 6-pyruvoyl-tetrahydropterin synthase Neighboring gene interleukin 18 Neighboring gene testis expressed 12 Neighboring gene succinate dehydrogenase complex subunit D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cellular localization of β-carotene 15,15' oxygenase-1 (BCO1) and β-carotene 9',10' oxygenase-2 (BCO2) in rat liver and intestine. Raghuvanshi S, et al. Arch Biochem Biophys, 2015 Apr 15. PMID 25575786, Free PMC Article
    2. Production of β-apo-10'-carotenal from β-carotene by human β-carotene-9',10'-oxygenase expressed in E. coli. Kim YS, et al. Biotechnol Lett, 2011 Jun. PMID 21302131
    3. A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. Amengual J, et al. FASEB J, 2011 Mar. PMID 21106934, Free PMC Article
    4. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. Kiefer C, et al. J Biol Chem, 2001 Apr 27. PMID 11278918
    5. A genetic dissection of intestinal fat-soluble vitamin and carotenoid absorption. Widjaja-Adhi MA, et al. Hum Mol Genet, 2015 Jun 1. PMID 25701869, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cellular localization of beta-carotene 15,15' oxygenase-1 (BCO1) and beta-carotene 9',10' oxygenase-2 (BCO2) in rat liver and intestine
      Title: Cellular localization of β-carotene 15,15' oxygenase-1 (BCO1) and β-carotene 9',10' oxygenase-2 (BCO2) in rat liver and intestine.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta,beta-carotene-9',10'-cleaving oxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-carotene 15,15'-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carotenoid dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carotene catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carotene catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carotene metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carotenoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinal metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retinal metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xanthophyll catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within xanthophyll metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carotenoid-cleaving dioxygenase, mitochondrial
    Names
    beta,beta-carotene 9',10'-oxygenase
    beta-carotene 9', 10'-dioxygenase 2
    carotenoid 9',10' monooxygenase II
    carotenoid 9',10' monoxygenase II
    NP_001121184.1
    XP_038937374.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127712.1 → NP_001121184.1  carotenoid-cleaving dioxygenase, mitochondrial

      See identical proteins and their annotated locations for NP_001121184.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133725
      UniProtKB/TrEMBL
      A3KN98
      Related
      ENSRNOP00000055965.2, ENSRNOT00000059192.6
      Conserved Domains (1) summary
      pfam03055
      Location:19 → 531
      RPE65; Retinal pigment epithelial membrane protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      59778571..59803597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081446.2 → XP_038937374.1  carotenoid-cleaving dioxygenase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A3KN98
      Conserved Domains (1) summary
      pfam03055
      Location:19 → 531
      RPE65; Retinal pigment epithelial membrane protein
    Nucleotide Protein Strain
    Heading Accession and Version

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