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    Carnmt1 carnosine N-methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293871, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Carnmt1provided by RGD
    Official Full Name
    carnosine N-methyltransferase 1provided by RGD
    Primary source
    RGD:1311863
    See related
    EnsemblRapid:ENSRNOG00000012872 AllianceGenome:RGD:1311863
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311863
    Summary
    Enables carnosine N-methyltransferase activity. Involved in carnosine metabolic process. Located in cytosol and nucleus. Orthologous to human CARNMT1 (carnosine N-methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 851.8), Heart (RPKM 165.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Carnmt1 in Genome Data Viewer
    Location:
    1q51
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (225520345..225549971)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (216093720..216123360)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (234675442..234704856, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene osteoclast stimulating factor 1 Neighboring gene ribosomal protein S15, pseudogene 7 Neighboring gene nicotinamide riboside kinase 1 Neighboring gene uncharacterized LOC134485209 Neighboring gene similar to human chromosome 9 open reading frame 40 Neighboring gene uncharacterized LOC102554711 Neighboring gene transient receptor potential cation channel, subfamily M, member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular basis for histidine N1 position-specific methylation by CARNMT1. Cao R, et al. Cell Res, 2018 Apr. PMID 29463897, Free PMC Article
    2. UPF0586 Protein C9orf41 Homolog Is Anserine-producing Methyltransferase. Drozak J, et al. J Biol Chem, 2015 Jul 10. PMID 26001783, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109119

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carnosine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carnosine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carnosine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnosine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carnosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carnosine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in carnosine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carnosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    carnosine N-methyltransferase
    Names
    UPF0586 protein C9orf41 homolog
    anserine-producing methyltransferase
    NP_001020145.1
    XP_038964749.1
    XP_038964759.1
    XP_038964762.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024974.1 → NP_001020145.1  carnosine N-methyltransferase

      See identical proteins and their annotated locations for NP_001020145.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091268
      UniProtKB/Swiss-Prot
      Q5BJZ6
      UniProtKB/TrEMBL
      A0A0G3F9V8, A0A0H2UHK4
      Related
      ENSRNOP00000017405.7, ENSRNOT00000017405.9
      Conserved Domains (1) summary
      pfam07942
      Location:135 → 400
      N2227; N2227-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      225520345..225549971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108831.2 → XP_038964759.1  carnosine N-methyltransferase isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:211 → 263
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_039108821.2 → XP_038964749.1  carnosine N-methyltransferase isoform X1

      Conserved Domains (1) summary
      cl17173
      Location:211 → 370
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_039108834.2 → XP_038964762.1  carnosine N-methyltransferase isoform X3

      Conserved Domains (1) summary
      pfam07942
      Location:1 → 262
      N2227; N2227-like protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJZ6.1 GenPept UniProtKB/Swiss-Prot:Q5BJZ6

    Gene LinkOut

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