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    CD22 CD22 molecule [ Pan troglodytes (chimpanzee) ]

    Gene ID: 450167, updated on 3-Dec-2024

    Summary

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    Official Symbol
    CD22provided by VGNC
    Official Full Name
    CD22 moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:2369
    Locus tag
    CK820_G0030195
    See related
    Ensembl:ENSPTRG00000010840 Ensembl:ENSPTRG00000024187
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Also known as
    MAG; SIGLEC2; siglec-2
    Orthologs
    human mouse all
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    Genomic context

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    See CD22 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 20 NC_072418.2 (38435193..38493903)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 19 NC_072417.1 (38435219..38492011)

    Chromosome 20 - NC_072418.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC129138056 Neighboring gene upstream transcription factor 2, c-fos interacting Neighboring gene hepcidin antimicrobial peptide Neighboring gene free fatty acid receptor 1 Neighboring gene free fatty acid receptor 3 Neighboring gene G protein-coupled receptor 42 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of N-glycolylneuraminic acid in human evolution. Implications for sialic acid recognition by siglecs. Brinkman-Van der Linden EC, et al. J Biol Chem, 2000 Mar 24. PMID 10722703
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables CD4 receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sialic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    B-cell receptor CD22
    Names
    CD22 antigen
    myelin associated glycoprotein
    sialic acid-binding Ig-like lectin 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072418.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      38435193..38493903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063800682.1 → XP_063656752.1  B-cell receptor CD22 isoform X6

    2. XM_063800683.1 → XP_063656753.1  B-cell receptor CD22 isoform X6

    3. XM_063800679.1 → XP_063656749.1  B-cell receptor CD22 isoform X3

    4. XM_016935677.4 → XP_016791166.1  B-cell receptor CD22 isoform X6

    5. XM_016935675.4 → XP_016791164.1  B-cell receptor CD22 isoform X1

    6. XM_016935678.4 → XP_016791167.1  B-cell receptor CD22 isoform X6

    7. XM_016935676.4 → XP_016791165.1  B-cell receptor CD22 isoform X4

    8. XM_063800686.1 → XP_063656756.1  B-cell receptor CD22 isoform X10

    9. XM_016935679.3 → XP_016791168.1  B-cell receptor CD22 isoform X8

    10. XM_016935674.4 → XP_016791163.1  B-cell receptor CD22 isoform X2

    11. XM_063800684.1 → XP_063656754.1  B-cell receptor CD22 isoform X7

    12. XM_063800680.1 → XP_063656750.1  B-cell receptor CD22 isoform X5

    13. XM_063800685.1 → XP_063656755.1  B-cell receptor CD22 isoform X9

    14. XM_063800701.1 → XP_063656771.1  B-cell receptor CD22 isoform X22

      UniProtKB/TrEMBL
      A0A2I3TS94, A0A2J8QH91, A0A2J8QHA7, A0A6D2WBJ9

    15. XM_016935681.3 → XP_016791170.1  B-cell receptor CD22 isoform X22

      UniProtKB/TrEMBL
      A0A2I3TS94, A0A2J8QH91, A0A2J8QHA7, A0A6D2WBJ9
      Related
      ENSPTRP00000092119.1
      Conserved Domains (4) summary
      cd05712
      Location:22 → 139
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      smart00410
      Location:333 → 409
      IG_like; Immunoglobulin like
      pfam13927
      Location:239 → 309
      Ig_3; Immunoglobulin domain
      cl11960
      Location:141 → 223
      Ig; Immunoglobulin domain

    16. XM_016935682.3 → XP_016791171.1  B-cell receptor CD22 isoform X21

      UniProtKB/TrEMBL
      A0A2J8QH91, A0A2J8QHD3, A0A6D2WUA3, H2R665
      Related
      ENSPTRP00000048802.3
      Conserved Domains (4) summary
      cd05712
      Location:22 → 139
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      smart00410
      Location:333 → 409
      IG_like; Immunoglobulin like
      pfam13927
      Location:239 → 309
      Ig_3; Immunoglobulin domain
      cl11960
      Location:141 → 223
      Ig; Immunoglobulin domain

    17. XM_009435311.5 → XP_009433586.1  B-cell receptor CD22 isoform X13

      Conserved Domains (6) summary
      smart00408
      Location:276 → 335
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:625 → 696
      IG_like; Immunoglobulin like
      pfam07679
      Location:261 → 346
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:162 → 247
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13927
      Location:354 → 419
      Ig_3; Immunoglobulin domain
      cl11960
      Location:43 → 141
      Ig; Immunoglobulin domain

    18. XM_009435312.5 → XP_009433587.1  B-cell receptor CD22 isoform X14

      Conserved Domains (6) summary
      smart00408
      Location:274 → 333
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:623 → 694
      IG_like; Immunoglobulin like
      pfam07679
      Location:259 → 344
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:160 → 245
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13927
      Location:352 → 417
      Ig_3; Immunoglobulin domain
      cl11960
      Location:41 → 139
      Ig; Immunoglobulin domain

    19. XM_063800694.1 → XP_063656764.1  B-cell receptor CD22 isoform X16

    20. XM_063800698.1 → XP_063656768.1  B-cell receptor CD22 isoform X19

      UniProtKB/TrEMBL
      A0A2J8QHF8

    21. XM_063800691.1 → XP_063656761.1  B-cell receptor CD22 isoform X15

      UniProtKB/Swiss-Prot
      A0A6D2WBT6, Q9N1E6
      UniProtKB/TrEMBL
      A0A2J8QHC7, H2QG24

    22. XM_063800687.1 → XP_063656757.1  B-cell receptor CD22 isoform X11

    23. XM_063800688.1 → XP_063656758.1  B-cell receptor CD22 isoform X12

    24. XM_063800690.1 → XP_063656760.1  B-cell receptor CD22 isoform X15

      UniProtKB/Swiss-Prot
      A0A6D2WBT6, Q9N1E6
      UniProtKB/TrEMBL
      A0A2J8QHC7, H2QG24

    25. XM_063800700.1 → XP_063656770.1  B-cell receptor CD22 isoform X20

      UniProtKB/TrEMBL
      A0A2I3SQY2, A0A2J8QHH2, A0A6D2XNK9

    26. XM_063800693.1 → XP_063656763.1  B-cell receptor CD22 isoform X16

    27. XM_063800697.1 → XP_063656767.1  B-cell receptor CD22 isoform X19

      UniProtKB/TrEMBL
      A0A2J8QHF8

    28. XM_063800689.1 → XP_063656759.1  B-cell receptor CD22 isoform X15

      UniProtKB/Swiss-Prot
      A0A6D2WBT6, Q9N1E6
      UniProtKB/TrEMBL
      A0A2J8QHC7, H2QG24

    29. XM_063800696.1 → XP_063656766.1  B-cell receptor CD22 isoform X18

      UniProtKB/TrEMBL
      A0A2I3RQA0, A0A2J8QHI2, A0A6D2XTI3

    30. XM_063800695.1 → XP_063656765.1  B-cell receptor CD22 isoform X17

      UniProtKB/TrEMBL
      A0A2I3T384, A0A2J8QHA1, A0A6D2W3V7

    31. XM_063800699.1 → XP_063656769.1  B-cell receptor CD22 isoform X20

      UniProtKB/TrEMBL
      A0A2I3SQY2, A0A2J8QHH2, A0A6D2XNK9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N1E6.2 GenPept UniProtKB/Swiss-Prot:Q9N1E6

    Gene LinkOut

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