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    Tnfrsf11b TNF receptor superfamily member 11B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25341, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tnfrsf11bprovided by RGD
    Official Full Name
    TNF receptor superfamily member 11Bprovided by RGD
    Primary source
    RGD:619802
    See related
    EnsemblRapid:ENSRNOG00000008336 AllianceGenome:RGD:619802
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Opg
    Summary
    Predicted to enable heparan sulfate binding activity. Involved in several processes, including negative regulation of bone resorption; negative regulation of odontogenesis of dentin-containing tooth; and response to estrogen. Located in extracellular space. Biomarker of congestive heart failure; myocarditis; and periapical periodontitis. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 5; and osteoarthritis. Orthologous to human TNFRSF11B (TNF receptor superfamily member 11b). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 89.4), Uterus (RPKM 58.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tnfrsf11b in Genome Data Viewer
    Location:
    7q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (87456318..87484324, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (85566520..85594526, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (93798580..93826586, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit beta 7, pseudogene 2 Neighboring gene uncharacterized LOC120093858 Neighboring gene collectin subfamily member 10 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 72

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC93568

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparan sulfate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of bone resorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of odontogenesis of dentin-containing tooth IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of odontogenesis of dentin-containing tooth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to arsenic-containing substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to magnesium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor receptor superfamily member 11B
    Names
    Osteoprotegerin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012870.2NP_037002.1  tumor necrosis factor receptor superfamily member 11B precursor

      See identical proteins and their annotated locations for NP_037002.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081830
      UniProtKB/Swiss-Prot
      O08727
      UniProtKB/TrEMBL
      A0A8I6A1T0, A6HRF7
      Related
      ENSRNOP00000011344.3, ENSRNOT00000011344.7
      Conserved Domains (4) summary
      cd00185
      Location:145186
      TNFRSF; CRD2 [structural motif]
      cd10581
      Location:7151
      TNFRSF11B; Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), also known as Osteoprotegerin (OPG)
      pfam00531
      Location:288365
      Death; Death domain
      cl22855
      Location:124187
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      87456318..87484324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)