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    Angptl8 angiopoietin-like 8 [ Mus musculus (house mouse) ]

    Gene ID: 624219, updated on 9-Dec-2024

    Summary

    Official Symbol
    Angptl8provided by MGI
    Official Full Name
    angiopoietin-like 8provided by MGI
    Primary source
    MGI:MGI:3643534
    See related
    Ensembl:ENSMUSG00000047822 AllianceGenome:MGI:3643534
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rifl; Gm6484; EG624219
    Summary
    Predicted to enable hormone activity. Involved in several processes, including fat cell differentiation; regulation of lipoprotein metabolic process; and triglyceride homeostasis. Acts upstream of or within cell maturation. Predicted to be active in extracellular region. Orthologous to human ANGPTL8 (angiopoietin like 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E18 (RPKM 107.6), liver adult (RPKM 87.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Angptl8 in Genome Data Viewer
    Location:
    9 A3; 9 7.9 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21746806..21748643)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21835510..21837347)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 6 Neighboring gene predicted gene, 39305 Neighboring gene microRNA 7083 Neighboring gene STARR-seq mESC enhancer starr_23526 Neighboring gene STARR-seq mESC enhancer starr_23527 Neighboring gene RAB3D, member RAS oncogene family Neighboring gene transmembrane protein 205 Neighboring gene coiled-coil domain containing 159

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of lipoprotein lipase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lipoprotein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of lipoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in triglyceride homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    NOT involved_in type B pancreatic cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in type B pancreatic cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    angiopoietin-like protein 8
    Names
    betatrophin
    hepatocellular carcinoma-associated protein TD26 homolog
    lipasin
    refeeding-induced fat and liver protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080940.1NP_001074409.1  angiopoietin-like protein 8 precursor

      See identical proteins and their annotated locations for NP_001074409.1

      Status: VALIDATED

      Source sequence(s)
      BC038127, BC051501, CK791522
      Consensus CDS
      CCDS40556.1
      UniProtKB/Swiss-Prot
      Q8R1L8
      UniProtKB/TrEMBL
      A0A0A0R784, A0A1P9FG12
      Related
      ENSMUSP00000058951.7, ENSMUST00000058777.8
      Conserved Domains (1) summary
      pfam15351
      Location:13120
      JCAD; Junctional protein associated with coronary artery disease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21746806..21748643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)