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    Sytl1 synaptotagmin-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297872, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sytl1provided by RGD
    Official Full Name
    synaptotagmin-like 1provided by RGD
    Primary source
    RGD:1310715
    See related
    EnsemblRapid:ENSRNOG00000008600 AllianceGenome:RGD:1310715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Slp-1
    Summary
    Predicted to enable neurexin family protein binding activity. Predicted to be involved in exocytosis. Predicted to be located in melanosome and membrane. Predicted to be active in exocytic vesicle and plasma membrane. Orthologous to human SYTL1 (synaptotagmin like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 64.0), Lung (RPKM 28.2) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sytl1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (150736425..150746840, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (145452524..145462940, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (151448639..151459870, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene CD164 molecule like 2 Neighboring gene mitogen-activated protein kinase kinase kinase 6 Neighboring gene transmembrane protein 222 Neighboring gene uncharacterized LOC134487005 Neighboring gene WD and tetratricopeptide repeats 1 Neighboring gene uncharacterized LOC134487006

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Arimura N, et al. Dev Cell, 2009 May. PMID 19460344
    2. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. Holt O, et al. Traffic, 2008 Apr. PMID 18266782, Free PMC Article
    3. Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins. Fukuda M, et al. Biochem Biophys Res Commun, 2001 Mar. PMID 11243866
    4. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. Kuroda TS, et al. J Biol Chem, 2002 Mar 15. PMID 11773082
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112642

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurexin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in melanosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-like protein 1
    Names
    exophilin-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025651.1 → NP_001020822.1  synaptotagmin-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001020822.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098679
      UniProtKB/TrEMBL
      A0A0G2K2R4, A6ISW2, Q4KMA1
      Related
      ENSRNOP00000061610.1, ENSRNOT00000064472.4
      Conserved Domains (4) summary
      cd04020
      Location:399 → 517
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      pfam05466
      Location:121 → 229
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl14603
      Location:267 → 386
      C2; C2 domain
      cl22851
      Location:35 → 99
      PHD_SF; PHD finger superfamily

    2. NM_001399037.1 → NP_001385966.1  synaptotagmin-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      Related
      ENSRNOP00000072343.2, ENSRNOT00000087836.3
      Conserved Domains (3) summary
      cd04020
      Location:399 → 555
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:267 → 386
      C2; C2 domain
      cl22851
      Location:35 → 90
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      150736425..150746840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109413.2 → XP_038965341.1  synaptotagmin-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2R4, A6ISW2
      Conserved Domains (3) summary
      cd04020
      Location:399 → 555
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:267 → 386
      C2; C2 domain
      cl22851
      Location:35 → 90
      PHD_SF; PHD finger superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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