Nbl1 NBL1, DAN family BMP antagonist [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nbl1provided by MGI
Official Full Name: NBL1, DAN family BMP antagonistprovided by MGI
Primary source: MGI:MGI:104591
See related: Ensembl:ENSMUSG00000041120 AllianceGenome:MGI:104591
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DAN; NO3; Dana; D4H1S1733E
Summary: Enables BMP binding activity and morphogen activity. Involved in several processes, including determination of dorsal identity; negative regulation of monocyte chemotaxis; and sequestering of BMP in extracellular matrix. Acts upstream of or within negative regulation of BMP signaling pathway; neuron projection morphogenesis; and positive regulation of neuron differentiation. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain ventricular layer; embryo mesenchyme; limb; and nose. Orthologous to human MICOS10-NBL1 (MICOS10-NBL1 readthrough) and NBL1 (NBL1, DAN family BMP antagonist). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary adult (RPKM 159.8), lung adult (RPKM 140.6) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 70.57 cM; 4 D3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (138809602..138820437, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (139082291..139093126, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DAN is a novel autocrine/paracrine factor that modulates GnRH function in pituitary gonadotropes.
Title: GnRH-mediated DAN production regulates the transcription of the GnRH receptor in gonadotrope cells.
Dan expression during murine forebrain development from embryonic day 10.5 to postnatal day 14 and found that Dan was expressed in highly specific spatiotemporal patterns.
Title: Expression of the BMP antagonist Dan during murine forebrain development.
Data using DAN-deficient mice to investigate thermal and mechanical allodynia and Fos expression in the spinal dorsal horn suggest that Dan may be a neuromodulator in inflammatory pain.
Title: Reduced inflammatory pain in mice deficient in the differential screening-selected gene aberrative in neuroblastoma.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:224311 (e-PCR)
- UniSTS:224311

NoName (e-PCR)
- UniSTS:489089

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables BMP binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables morphogen activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in determination of dorsal identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of monocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron projection morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in sequestering of BMP from receptor via BMP binding	IBA Inferred from Biological aspect of Ancestor more info
involved_in sequestering of BMP from receptor via BMP binding	IEA Inferred from Electronic Annotation more info
involved_in sequestering of BMP in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: neuroblastoma suppressor of tumorigenicity 1

Names: N03; neuroblastoma, suppression of tumorigenicity 1; zinc finger protein DAN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008675.2 → NP_032701.2 neuroblastoma suppressor of tumorigenicity 1 precursor

See identical proteins and their annotated locations for NP_032701.2

Status: VALIDATED

Source sequence(s)

AK146535

Consensus CDS

CCDS18839.1

UniProtKB/Swiss-Prot

Q499K5, Q61477

Related

ENSMUSP00000045608.7, ENSMUST00000042844.7

Conserved Domains (1) summary

pfam03045
Location:22 → 120

DAN; DAN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

138809602..138820437 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030253300.1 → XP_030109160.1 neuroblastoma suppressor of tumorigenicity 1 isoform X2

UniProtKB/Swiss-Prot

Q499K5, Q61477

Conserved Domains (1) summary

pfam03045
Location:22 → 120

DAN; DAN domain
XM_036163807.1 → XP_036019700.1 neuroblastoma suppressor of tumorigenicity 1 isoform X1

Conserved Domains (1) summary

pfam03045
Location:71 → 169

DAN; DAN domain
XM_006538625.5 → XP_006538688.1 neuroblastoma suppressor of tumorigenicity 1 isoform X2

See identical proteins and their annotated locations for XP_006538688.1

UniProtKB/Swiss-Prot

Q499K5, Q61477

Conserved Domains (1) summary

pfam03045
Location:22 → 120

DAN; DAN domain
XM_030253299.2 → XP_030109159.1 neuroblastoma suppressor of tumorigenicity 1 isoform X2

UniProtKB/Swiss-Prot

Q499K5, Q61477

Conserved Domains (1) summary

pfam03045
Location:22 → 120

DAN; DAN domain
XM_036163808.1 → XP_036019701.1 neuroblastoma suppressor of tumorigenicity 1 isoform X2

UniProtKB/Swiss-Prot

Q499K5, Q61477

Conserved Domains (1) summary

pfam03045
Location:22 → 120

DAN; DAN domain
XM_030253301.2 → XP_030109161.1 neuroblastoma suppressor of tumorigenicity 1 isoform X2

UniProtKB/Swiss-Prot

Q499K5, Q61477

Conserved Domains (1) summary

pfam03045
Location:22 → 120

DAN; DAN domain
XM_036163809.1 → XP_036019702.1 neuroblastoma suppressor of tumorigenicity 1 isoform X3

Conserved Domains (1) summary

pfam03045
Location:57 → 155

DAN; DAN domain