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    tlk-1 Protein kinase domain-containing protein;Serine/threonine-protein kinase tousled-like 1 [ Caenorhabditis elegans ]

    Gene ID: 176369, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tlk-1
    Official Full Name
    Protein kinase domain-containing protein;Serine/threonine-protein kinase tousled-like 1
    Primary source
    WormBase:WBGene00006579
    Locus tag
    CELE_C07A9.3
    See related
    AllianceGenome:WB:WBGene00006579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein kinase activity. Involved in regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in several structures, including germ line; intestine; pharynx; posterior lateral ganglion; and somatic cell. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to several human genes including TLK2 (tousled like kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tlk-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (9699876..9710268)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein BUD31 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Putative sodium/calcium exchanger 6 Neighboring gene Putative sodium/calcium exchanger 7 Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein 162

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription elongation: TLKing to chromatin? Blackwell TK, et al. Curr Biol, 2003 Dec 2. PMID 14654017
    2. Maintenance of cell fates and regulation of the histone variant H3.3 by TLK kinase in Caenorhabditis elegans. Shibata Y, et al. Biol Open, 2019 Jan 17. PMID 30635266, Free PMC Article
    3. Caenorhabditis elegans TLK-1 controls cytokinesis by localizing AIR-2/Aurora B to midzone microtubules. Yeh CH, et al. Biochem Biophys Res Commun, 2010 Sep 17. PMID 20705056
    4. Tousled-mediated activation of Aurora B kinase does not require Tousled kinase activity in vivo. Riefler GM, et al. J Biol Chem, 2008 May 9. PMID 18334486, Free PMC Article
    5. The C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase. Han Z, et al. Curr Biol, 2005 May 24. PMID 15916946, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TLK-1 contributes to chromosome condensation and segregation;TLK-1 functions in cytokinesis by localizing AIR-2 to the midzone microtubules.
      Title: Caenorhabditis elegans TLK-1 controls cytokinesis by localizing AIR-2/Aurora B to midzone microtubules.
    2. Tousled-like kinase (TLK-1) contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase AIR-2.
      Title: The C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein kinase domain-containing protein;Serine/threonine-protein kinase tousled-like 1
    NP_001255017.1
    • Confirmed by transcript evidence
    NP_001370213.1
    • Confirmed by transcript evidence
    NP_499145.2
    • Confirmed by transcript evidence
    NP_871642.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9699876..9710268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066744.6 → NP_499145.2  Serine/threonine-protein kinase tousled-like 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499145.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34314
      Conserved Domains (2) summary
      smart00220
      Location:651 → 928
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13990
      Location:650 → 926
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase

    2. NM_181913.5 → NP_871642.2  Serine/threonine-protein kinase tousled-like 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871642.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34314, P34323, Q6SSJ1, Q8I4N0
      Conserved Domains (2) summary
      smart00220
      Location:651 → 928
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13990
      Location:650 → 926
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase

    3. NM_001382967.2 → NP_001370213.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XN10
      Conserved Domains (1) summary
      cd13990
      Location:583 → 859
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase

    4. NM_001268088.3 → NP_001255017.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MTX3
      Conserved Domains (1) summary
      cd13990
      Location:569 → 845
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34314.3

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