rfp-1 E3 ubiquitin-protein ligase bre-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rfp-1
Official Full Name: E3 ubiquitin-protein ligase bre-1
Primary source: WormBase:WBGene00007008
Locus tag: CELE_R05D3.4
See related: AllianceGenome:WB:WBGene00007008
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ubiquitin conjugating enzyme binding activity. Involved in glycolipid metabolic process. Located in nucleus. Is expressed in germ line; intestinal cell; nerve ring; oocyte; and pharynx. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RNF20 (ring finger protein 20) and RNF40 (ring finger protein 40). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rfp-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (8358622..8362543)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lack of RFP-1 expression increases levels of MRG-1 and a shift towards increased proliferation in sensitized genetic backgrounds.
Title: Proteasome regulation of the chromodomain protein MRG-1 controls the balance between proliferative fate and differentiation in the C. elegans germ line.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R05D3.8 (e-PCR)
- UniSTS:316943

R05D3.4 (e-PCR)
- UniSTS:312049

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in glycolipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of HULC complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase bre-1

NP_001022699.1

Confirmed by transcript evidence

NP_001022700.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8358622..8362543

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027529.6 → NP_001022700.1 E3 ubiquitin-protein ligase bre-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022700.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34537, Q65ZS6

Conserved Domains (1) summary

pfam00097
Location:785 → 823

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
NM_001027528.6 → NP_001022699.1 E3 ubiquitin-protein ligase bre-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022699.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34537

Conserved Domains (1) summary

pfam00097
Location:782 → 820

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)