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    scrm-1 Phospholipid scramblase [ Caenorhabditis elegans ]

    Gene ID: 173053, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scrm-1
    Official Full Name
    Phospholipid scramblase
    Primary source
    WormBase:WBGene00011935
    Locus tag
    CELE_T22H2.5
    See related
    AllianceGenome:WB:WBGene00011935
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables phospholipid scramblase activity. Involved in phosphatidylserine exposure on apoptotic cell surface. Located in plasma membrane. Is expressed in several structures, including germ line. Orthologous to several human genes including PLSCR2 (phospholipid scramblase 2); PLSCR3 (phospholipid scramblase 3); and PLSCR4 (phospholipid scramblase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See scrm-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (11688673..11690836, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene 4Fe-4S ferredoxin-type domain-containing protein Neighboring gene Serpentine Receptor, class I Neighboring gene G protein-coupled receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cholesterol interaction attenuates scramblase activity of SCRM-1 in the artificial membrane. Koyiloth M, et al. Biochim Biophys Acta Biomembr, 2021 Sep 1. PMID 33417966
    2. Molecular cloning and biochemical characterization of the phospholipid scramblase SCRM-1 from Caenorhabditis elegans. Koyiloth M, et al. Eur Biophys J, 2020 Mar. PMID 32020261
    3. Engulfment of apoptotic cells in C. elegans is mediated by integrin alpha/SRC signaling. Hsu TY, et al. Curr Biol, 2010 Mar 23. PMID 20226672
    4. Two alternative mechanisms that regulate the presentation of apoptotic cell engulfment signal in Caenorhabditis elegans. Venegas V, et al. Mol Biol Cell, 2007 Aug. PMID 17567952, Free PMC Article
    5. Programmed cell clearance: From nematodes to humans. Klöditz K, et al. Biochem Biophys Res Commun, 2017 Jan 15. PMID 27919685, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cholesterol interaction attenuates scramblase activity of SCRM-1 in the artificial membrane.
      Title: Cholesterol interaction attenuates scramblase activity of SCRM-1 in the artificial membrane.
    2. Molecular cloning and biochemical characterization of the phospholipid scramblase SCRM-1 from Caenorhabditis elegans.
      Title: Molecular cloning and biochemical characterization of the phospholipid scramblase SCRM-1 from Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phospholipid scramblase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid scramblase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid scramblase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphatidylserine exposure on apoptotic cell surface IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in plasma membrane phospholipid scrambling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane phospholipid scrambling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in plasma membrane phospholipid scrambling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Phospholipid scramblase
    NP_001251705.1
    • Confirmed by transcript evidence
    NP_001379216.1
    • Confirmed by transcript evidence
    NP_492976.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      11688673..11690836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392951.1 → NP_001379216.1  Phospholipid scramblase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5HBK2, Q7JKP1
      Conserved Domains (1) summary
      pfam03803
      Location:51 → 280
      Scramblase

    2. NM_060575.6 → NP_492976.2  Phospholipid scramblase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492976.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5HBK2, O45798, O45799
      Conserved Domains (1) summary
      pfam03803
      Location:51 → 280
      Scramblase; Scramblase

    3. NM_001264776.4 → NP_001251705.1  Phospholipid scramblase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251705.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5HBK2, G3MU68
      Conserved Domains (1) summary
      pfam03803
      Location:51 → 280
      Scramblase; Scramblase
    Nucleotide Protein
    Heading Accession and Version

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