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    flp-11 SPLDEEDFAPESPLQ-amide [ Caenorhabditis elegans ]

    Gene ID: 180741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    flp-11
    Official Full Name
    SPLDEEDFAPESPLQ-amide
    Primary source
    WormBase:WBGene00001454
    Locus tag
    CELE_K02G10.4
    See related
    AllianceGenome:WB:WBGene00001454
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables neuropeptide receptor binding activity. Involved in neuropeptide signaling pathway and sleep. Predicted to be located in extracellular region. Is expressed in head muscle; nerve ring; neurons; and uv1. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See flp-11 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    3
    Sequence:
    Chromosome: X; NC_003284.9 (4677334..4678129, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Nuclear Hormone Receptor family Neighboring gene Major facilitator superfamily domain-containing protein 12 Neighboring gene Transmembrane protein 135 homolog Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Novel Way of Amelioration of Amyloid Beta Induced Toxicity in Caenorhabditis elegans. Saharia K, et al. Ann Neurosci, 2016 Sep. PMID 27721583, Free PMC Article
    2. A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics. Steuer Costa W, et al. Nat Commun, 2019 Sep 10. PMID 31506439, Free PMC Article
    3. Unraveling flp-11/flp-32 dichotomy in nematodes. Atkinson LE, et al. Int J Parasitol, 2016 Oct. PMID 27451358, Free PMC Article
    4. Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior. Banerjee N, et al. PLoS Genet, 2017 Apr. PMID 28384151, Free PMC Article
    5. Characterization of an RFamide-related peptide orphan GPCR in C. elegans. Mertens I, et al. Ann N Y Acad Sci, 2005 Apr. PMID 15891075

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We demonstrate that the modulatory effects of the uv1 cells are mediated by peptides encoded by the nlp-7 and flp-11 genes that act locally to inhibit circuit activity, primarily by inhibiting vesicular release of serotonin from HSN motor neurons.
      Title: Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior.
    2. At sleep onset RIS depolarizes and releases FLP-11 to induce a systemic sleep state.
      Title: Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables neuropeptide receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SPLDEEDFAPESPLQ-amide
    NP_001024752.1
    • Confirmed by transcript evidence
    NP_001024753.1
    • Confirmed by transcript evidence
    NP_001024754.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4677334..4678129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029581.9 → NP_001024752.1  SPLDEEDFAPESPLQ-amide [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024752.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61467, Q21156, Q7Z140

    2. NM_001029582.4 → NP_001024753.1  SPLDEEDFAPESPLQ-amide [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024753.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21156

    3. NM_001029583.4 → NP_001024754.1  SPLDEEDFAPESPLQ-amide [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024754.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21156
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21156.1

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