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    fce-2 CAAX prenyl protease 2 [ Caenorhabditis elegans ]

    Gene ID: 3565253, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fce-2
    Official Full Name
    CAAX prenyl protease 2
    Primary source
    WormBase:WBGene00001406
    Locus tag
    CELE_F48F5.5
    See related
    AllianceGenome:WB:WBGene00001406
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cysteine-type endopeptidase activity. Involved in CAAX-box protein processing. Located in membrane. Orthologous to human RCE1 (Ras converting CAAX endopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fce-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (20425301..20431297)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CaeNaCin (Caenorhabditis bacteriocin) Neighboring gene ncRNA Neighboring gene WW domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans. Cadiñanos J, et al. Biochem J, 2003 Mar 15. PMID 12487630, Free PMC Article
    2. The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans. Brinzer RA, et al. G3 (Bethesda), 2024 Mar 6. PMID 38227795, Free PMC Article
    3. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results indicate that CeFACE-1 and CeFACE-2 are bona fide CaaX proteases and support the evolutionary conservation of this proteolytic system in eukaryotes.
      Title: Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CAAX-box protein maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CAAX-box protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CAAX-box protein processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in CAAX-box protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CAAX prenyl protease 2
    NP_001023947.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20425301..20431297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028776.4 → NP_001023947.1  CAAX prenyl protease 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023947.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEP3
      Conserved Domains (1) summary
      pfam02517
      Location:118 → 221
      Abi; CAAX protease self-immunity
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EEP3.1

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