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    lad-2 Ig-like domain-containing protein;Neuroglian [ Caenorhabditis elegans ]

    Gene ID: 177078, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lad-2
    Official Full Name
    Ig-like domain-containing protein;Neuroglian
    Primary source
    WormBase:WBGene00002243
    Locus tag
    CELE_Y54G2A.25
    See related
    AllianceGenome:WB:WBGene00002243
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables semaphorin receptor activity. Involved in anterior/posterior axon guidance; dorsal/ventral axon guidance; and regulation of axon guidance. Located in plasma membrane. Is expressed in lumbar neurons and nerve ring neurons. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to several human genes including L1CAM (L1 cell adhesion molecule). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lad-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    24
    Sequence:
    Chromosome: IV; NC_003282.8 (2964334..2978484, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Molybdate-anion transporter Neighboring gene pseudo Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene CUB_2 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Harmonization of L1CAM expression facilitates axon outgrowth and guidance of a motor neuron. Sherry T, et al. Development, 2020 Oct 26. PMID 32994172
    2. The C. elegans L1CAM homologue LAD-2 functions as a coreceptor in MAB-20/Sema2 mediated axon guidance. Wang X, et al. J Cell Biol, 2008 Jan 14. PMID 18195110, Free PMC Article
    3. EFN-4 functions in LAD-2-mediated axon guidance in Caenorhabditis elegans. Dong B, et al. Development, 2016 Apr 1. PMID 26903502, Free PMC Article
    4. "CRASH"ing with the worm: insights into L1CAM functions and mechanisms. Chen L, et al. Dev Dyn, 2010 May. PMID 20225255, Free PMC Article
    5. Axon-Dependent Patterning and Maintenance of Somatosensory Dendritic Arbors. Ramirez-Suarez NJ, et al. Dev Cell, 2019 Jan 28. PMID 30661986, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LAD-2, a Caenorhabditis elegans L1CAM, functions in axon pathfinding.
      Title: The C. elegans L1CAM homologue LAD-2 functions as a coreceptor in MAB-20/Sema2 mediated axon guidance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables semaphorin receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in semaphorin-plexin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ig-like domain-containing protein;Neuroglian
    NP_001023496.1
    • Confirmed by transcript evidence
    NP_001023497.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2964334..2978484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028325.3 → NP_001023496.1  Neuroglian [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023496.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECX2
      Conserved Domains (6) summary
      cd04978
      Location:344 → 422
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      smart00410
      Location:244 → 325
      IG_like; Immunoglobulin like
      cd00063
      Location:921 → 1010
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:335 → 421
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:823 → 909
      fn3; Fibronectin type III domain
      cl11960
      Location:49 → 121
      Ig; Immunoglobulin domain

    2. NM_001028326.4 → NP_001023497.1  Ig-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023497.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5JVN7, H2L0R2
      Conserved Domains (4) summary
      cd04978
      Location:344 → 422
      Ig4_L1-NrCAM_like; Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related)
      smart00410
      Location:244 → 325
      IG_like; Immunoglobulin like
      pfam07679
      Location:335 → 421
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:49 → 121
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version

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