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    Chd64 Chd64 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38490, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Chd64provided by FlyBase
    Official Full Name
    Chd64provided by FlyBase
    Primary source
    FLYBASE:FBgn0035499
    Locus tag
    Dmel_CG14996
    See related
    AllianceGenome:FB:FBgn0035499
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.80; CG-14996; CG14996; clone 1.80; CT34849; Dmel\CG14996
    Summary
    Enables juvenile hormone response element binding activity. Involved in juvenile hormone mediated signaling pathway. Predicted to be located in striated muscle thin filament. Predicted to be active in actin cytoskeleton. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; epithelium; germline cell; and gut section. Orthologous to human TAGLN (transgelin); TAGLN2 (transgelin 2); and TAGLN3 (transgelin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Chd64 in Genome Data Viewer
    Location:
    64A6-64A7; 3-10 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4114289..4122388, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4114289..4122388, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45670 Neighboring gene Activated Cdc42 kinase Neighboring gene ensconsin Neighboring gene Replication factor C subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insight into the Unfolding Properties of Chd64, a Small, Single Domain Protein with a Globular Core and Disordered Tails. Tarczewska A, et al. PLoS One, 2015. PMID 26325194, Free PMC Article
    2. Calponin-like Chd64 is partly disordered. Kozłowska M, et al. PLoS One, 2014. PMID 24805353, Free PMC Article
    3. Differential Expression of Drosophila Transgelins Throughout Development. Vakaloglou KM, et al. Front Cell Dev Biol, 2021. PMID 34322481, Free PMC Article
    4. Leading edge-secreted Dpp cooperates with ACK-dependent signaling from the amnioserosa to regulate myosin levels during dorsal closure. Zahedi B, et al. Dev Dyn, 2008 Oct. PMID 18816840
    5. Drosophila ensconsin promotes productive recruitment of Kinesin-1 to microtubules. Sung HH, et al. Dev Cell, 2008 Dec. PMID 19081075

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables juvenile hormone response element binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in juvenile hormone mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in striated muscle thin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Chd64
    Names
    CG14996-PB
    CG14996-PC
    Chd64-PB
    Chd64-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4114289..4122388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139603.3 → NP_647860.1  Chd64, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647860.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NHZ2, Q9VZI1
      Related
      FBpp0073126
      Conserved Domains (2) summary
      pfam00402
      Location:165 → 187
      Calponin; Calponin family repeat
      cl00030
      Location:22 → 131
      CH_SF; calponin homology (CH) domain superfamily

    2. NM_001274469.1 → NP_001261398.1  Chd64, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261398.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE30
      Conserved Domains (2) summary
      pfam00402
      Location:152 → 174
      Calponin; Calponin family repeat
      cl00030
      Location:9 → 118
      CH_SF; calponin homology (CH) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PE30 M9PE30
    Q9VZI1 Q9VZI1

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