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    brv1 brivido-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40116, updated on 9-Dec-2024

    Summary

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    Official Symbol
    brv1provided by FlyBase
    Official Full Name
    brivido-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0036874
    Locus tag
    Dmel_CG9472
    See related
    AllianceGenome:FB:FBgn0036874
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Brivido 1; Brivido1; brv; Brv-1; Brv1; CG9472; CT26822; Dmel\CG9472
    Summary
    Enables stretch-activated, monoatomic cation-selective, calcium channel activity. Involved in cellular response to cold; detection of mechanical stimulus involved in sensory perception of touch; and detection of temperature stimulus involved in thermoception. Predicted to be active in membrane. Is expressed in antennal lobe glomerulus VP3; aristal sensory neuron VP3; sacculus; and second segment of antenna. Orthologous to human PKD1L3 (polycystin 1 like 3, transient receptor potential channel interacting). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See brv1 in Genome Data Viewer
    Location:
    76B3-76B3; 3-45 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19483826..19486498, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19476926..19479598, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene hairpin RNA:CR32207 Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene hairpin RNA:CR33940 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Injury-induced cold sensitization in Drosophila larvae involves behavioral shifts that require the TRP channel Brv1. Turner HN, et al. PLoS One, 2018. PMID 30586392, Free PMC Article
    2. Brv1 Is Required for Drosophila Larvae to Sense Gentle Touch. Zhang M, et al. Cell Rep, 2018 Apr 3. PMID 29617663
    3. A gustatory receptor paralogue controls rapid warmth avoidance in Drosophila. Ni L, et al. Nature, 2013 Aug 29. PMID 23925112, Free PMC Article
    4. The coding of temperature in the Drosophila brain. Gallio M, et al. Cell, 2011 Feb 18. PMID 21335241, Free PMC Article
    5. Temperature sensation in Drosophila. Barbagallo B, et al. Curr Opin Neurobiol, 2015 Oct. PMID 25616212, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables stretch-activated, monoatomic cation-selective, calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cellular response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of mechanical stimulus involved in sensory perception of touch IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of temperature stimulus involved in thermoception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    brivido-1
    Names
    CG9472-PA
    brivido
    brv1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19483826..19486498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140859.2 → NP_649116.1  brivido-1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVZ8
      Related
      FBpp0074750
      Conserved Domains (1) summary
      pfam08016
      Location:165 → 591
      PKD_channel; Polycystin cation channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVZ8 Q9VVZ8

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