DCTN2-p50 Dynactin 2, p50 subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: DCTN2-p50provided by FlyBase
Official Full Name: Dynactin 2, p50 subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0021825
Locus tag: Dmel_CG8269
See related: AllianceGenome:FB:FBgn0021825
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8269; DCTN2; dDyn; Dmel\CG8269; dmn; Dmn; DMN; dyna; Dynamitin; l(2)k16109; l(2)k16218; p50; P50; p50/Dmn; p50/dynamitin; p50[Dmn]
Summary: Involved in several processes, including clathrin-dependent endocytosis involved in vitellogenesis; oocyte construction; and positive regulation of retrograde axon cargo transport. Located in cell cortex. Colocalizes with axon cytoplasm. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. Used to study retinal degeneration. Orthologous to human DCTN2 (dynactin subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8891832..8893339)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4779337..4780844)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in centrosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin-dependent endocytosis involved in vitellogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA transport	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in oocyte microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm oskar mRNA localization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of retrograde axon cargo transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with axon cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of dynactin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dynactin complex	IEA Inferred from Electronic Annotation more info
part_of dynactin complex	ISS Inferred from Sequence or Structural Similarity more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info