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    RBG1 GTP-binding protein RBG1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851195, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RBG1
    Official Full Name
    GTP-binding protein RBG1
    Primary source
    SGD:S000000034
    Locus tag
    YAL036C
    See related
    AllianceGenome:SGD:S000000034; FungiDB:YAL036C; VEuPathDB:YAL036C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FUN11
    Summary
    Enables GTP binding activity. Involved in cytoplasmic translation and positive regulation of cellular response to amino acid starvation. Located in peroxisome. Orthologous to human DRG1 (developmentally regulated GTP binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RBG1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (75043..76152, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene translation initiation factor eIF5B Neighboring gene MIND complex subunit MTW1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rbg1-Tma46 dimer structure reveals new functional domains and their role in polysome recruitment. Francis SM, et al. Nucleic Acids Res, 2012 Nov. PMID 23002146, Free PMC Article
    2. The yeast GTPase Mtg2p is required for mitochondrial translation and partially suppresses an rRNA methyltransferase mutant, mrm2. Datta K, et al. Mol Biol Cell, 2005 Feb. PMID 15591131, Free PMC Article
    3. Cell growth control by stable Rbg2/Gir2 complex formation under amino acid starvation. Ishikawa K, et al. Genes Cells, 2013 Oct. PMID 23899355
    4. Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells. Zeng F, et al. Cell Rep, 2021 Oct 26. PMID 34706231, Free PMC Article
    5. DRG represents a family of two closely related GTP-binding proteins. Li B, et al. Biochim Biophys Acta, 2000 Apr 25. PMID 10760581

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells.
      Title: Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cellular response to amino acid starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GTP-binding protein RBG1
    NP_009364.1
    • Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid; localizes to cytosol and peroxisomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      75043..76152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178181.1 → NP_009364.1  TPA: GTP-binding protein RBG1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009364.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPI1, P39729
      UniProtKB/TrEMBL
      A7A0D1, B3LUX1, B5VDI3, C7GU41, C8Z3F5, G2W8J5, N1PAY7
      Conserved Domains (1) summary
      COG1163
      Location:1 → 369
      Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39729.1

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