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    rfbX polyisoprenol-linked O16-antigen repeat unit flippase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946557, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rfbX
    Official Full Name
    polyisoprenol-linked O16-antigen repeat unit flippase
    Primary source
    ECOCYC:EG11980
    Locus tag
    b2037
    See related
    ASAP:ABE-0006757
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2031; wzx; wzxB
    Summary
    RfbX, also known as WzxB, is a member of the Polysaccharide Transporter (PST) Family . [More information is available at EcoCyc: EG11980].
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    Genomic context

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    Sequence:
    NC_000913.3 (2108337..2109584, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative O-antigen polymerase Neighboring gene UDP-galactopyranose mutase Neighboring gene dTDP-4-dehydrorhamnose 3,5-epimerase Neighboring gene glucose-1-phosphate thymidylyltransferase 1 Neighboring gene dTDP-4-dehydrorhamnose reductase Neighboring gene dTDP-glucose 4,6-dehydratase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The activity of a putative polyisoprenol-linked sugar translocase (Wzx) involved in Escherichia coli O antigen assembly is independent of the chemical structure of the O repeat. Feldman MF, et al. J Biol Chem, 1999 Dec 3. PMID 10574995
    2. Function of the rfb gene cluster and the rfe gene in the synthesis of O antigen by Shigella dysenteriae 1. Klena JD, et al. Mol Microbiol, 1993 Jul. PMID 7692219
    3. Sequence and analysis of the O antigen gene (rfb) cluster of Escherichia coli O111. Bastin DA, et al. Gene, 1995 Oct 16. PMID 7590310
    4. Computer-based analyses of the protein constituents of transport systems catalysing export of complex carbohydrates in bacteria. Paulsen IT, et al. Microbiology (Reading), 1997 Aug. PMID 9274022
    5. Escherichia coli genes that reduce the lethal effects of stress. Han X, et al. BMC Microbiol, 2010 Feb 4. PMID 20128927, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in O antigen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polyisoprenol-linked O16-antigen repeat unit flippase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2108337..2109584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416541.1 polyisoprenol-linked O16-antigen repeat unit flippase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416541.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P37746
      Conserved Domains (1) summary
      pfam01943
      Location:8 → 278
      Polysacc_synt; Polysaccharide biosynthesis protein
    Nucleotide Protein
    Heading Accession and Version

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