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    Cyp4v3 cytochrome P450, family 4, subfamily v, polypeptide 3 [ Mus musculus (house mouse) ]

    Gene ID: 102294, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cyp4v3provided by MGI
    Official Full Name
    cytochrome P450, family 4, subfamily v, polypeptide 3provided by MGI
    Primary source
    MGI:MGI:2142763
    See related
    Ensembl:ENSMUSG00000079057 AllianceGenome:MGI:2142763
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyp4v2
    Summary
    Predicted to enable heme binding activity; iron ion binding activity; and long-chain fatty acid omega-hydroxylase activity. Predicted to be involved in fatty acid omega-oxidation. Predicted to be located in endoplasmic reticulum membrane. Is expressed in central nervous system; pancreas epithelium; and sensory organ. Used to study Bietti crystalline corneoretinal dystrophy. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 34.0), large intestine adult (RPKM 20.7) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Cyp4v3 in Genome Data Viewer
    Location:
    8 B1.1; 8 25.17 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (45758838..45786200, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (45305801..45333163, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30504 Neighboring gene coagulation factor XI Neighboring gene kallikrein B, plasma 1 Neighboring gene family with sequence similarity 149, member A Neighboring gene toll-like receptor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6)  1 citation
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: Klkb1

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acid omega-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in fatty acid omega-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid omega-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cytochrome P450 4V2
    Names
    cytochrome P450 4V3
    docosahexaenoic acid omega-hydroxylase CYP4V2
    long-chain fatty acid omega-monooxygenase
    NP_598730.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133969.3NP_598730.1  cytochrome P450 4V2

      Status: VALIDATED

      Source sequence(s)
      AC120003
      Consensus CDS
      CCDS22276.1
      UniProtKB/Swiss-Prot
      Q9DBW0
      UniProtKB/TrEMBL
      B2RSR0, Q3UC74
      Related
      ENSMUSP00000092966.5, ENSMUST00000095328.6
      Conserved Domains (1) summary
      pfam00067
      Location:51517
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      45758838..45786200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)