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    Mul1 mitochondrial ubiquitin ligase activator of NFKB 1 [ Mus musculus (house mouse) ]

    Gene ID: 68350, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mul1provided by MGI
    Official Full Name
    mitochondrial ubiquitin ligase activator of NFKB 1provided by MGI
    Primary source
    MGI:MGI:1915600
    See related
    Ensembl:ENSMUSG00000041241 AllianceGenome:MGI:1915600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gide; 0610009K11Rik
    Summary
    Predicted to enable several functions, including p53 binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including positive regulation of dendrite extension; positive regulation of type 2 mitophagy; and regulation of protein stability. Located in mitochondrion. Orthologous to human MUL1 (mitochondrial E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 21.6), colon adult (RPKM 15.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mul1 in Genome Data Viewer
    Location:
    4 D3; 4 70.28 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138160239..138169576)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138434660..138442265)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene hypothetical protein, MNCb-2457 Neighboring gene family with sequence similarity 43, member B Neighboring gene ribosomal protein L38, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E8003 Neighboring gene STARR-seq mESC enhancer starr_11803 Neighboring gene STARR-seq mESC enhancer starr_11805 Neighboring gene STARR-seq mESC enhancer starr_11806 Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 1 Neighboring gene predicted gene, 32549

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SUMO transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to exogenous dsRNA ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrion localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of chemokine (C-C motif) ligand 5 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of chemokine (C-C motif) ligand 5 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of defense response to virus by host ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of mitochondrial fusion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of type I interferon-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dendrite extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type 2 mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein destabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitochondrial membrane potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    mitochondrial ubiquitin ligase activator of NFKB 1
    Names
    E3 ubiquitin ligase
    E3 ubiquitin-protein ligase MUL1
    RING-type E3 ubiquitin transferase NFKB 1
    growth inhibition and death E3 ligase
    protein Hades
    NP_080965.2
    XP_006539197.1
    XP_036020280.1
    XP_036020281.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026689.3NP_080965.2  mitochondrial ubiquitin ligase activator of NFKB 1

      See identical proteins and their annotated locations for NP_080965.2

      Status: VALIDATED

      Source sequence(s)
      AK076419, AK083295, BB856128, BY062056
      Consensus CDS
      CCDS18828.1
      UniProtKB/Swiss-Prot
      A2AM82, A2AM84, B5M498, Q3TDK4, Q8BHF2, Q8VCM5, Q9DCV9
      Related
      ENSMUSP00000039604.5, ENSMUST00000044058.11
      Conserved Domains (2) summary
      pfam12483
      Location:97251
      GIDE; E3 Ubiquitin ligase
      pfam13920
      Location:302346
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      138160239..138169576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539134.5XP_006539197.1  mitochondrial ubiquitin ligase activator of NFKB 1 isoform X2

      See identical proteins and their annotated locations for XP_006539197.1

      UniProtKB/Swiss-Prot
      Q8VCM5
      Related
      ENSMUSP00000101439.2, ENSMUST00000105813.8
      Conserved Domains (2) summary
      cd16648
      Location:296335
      mRING-HC-C3HC5_MAPL; Modified RING finger, HC subclass (C3HC5-type), found in mitochondrial-anchored protein ligase (MAPL) and similar proteins
      pfam12483
      Location:92248
      GIDE; E3 Ubiquitin ligase
    2. XM_036164388.1XP_036020281.1  mitochondrial ubiquitin ligase activator of NFKB 1 isoform X3

      Conserved Domains (2) summary
      cd16648
      Location:201240
      mRING-HC-C3HC5_MAPL; Modified RING finger, HC subclass (C3HC5-type), found in mitochondrial-anchored protein ligase (MAPL) and similar proteins
      pfam12483
      Location:3153
      GIDE; E3 Ubiquitin ligase
    3. XM_036164387.1XP_036020280.1  mitochondrial ubiquitin ligase activator of NFKB 1 isoform X1

      Conserved Domains (2) summary
      cd16648
      Location:327366
      mRING-HC-C3HC5_MAPL; Modified RING finger, HC subclass (C3HC5-type), found in mitochondrial-anchored protein ligase (MAPL) and similar proteins
      pfam12483
      Location:123279
      GIDE; E3 Ubiquitin ligase