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    Spc25 Spc25 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41585, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spc25provided by FlyBase
    Official Full Name
    Spc25provided by FlyBase
    Primary source
    FLYBASE:FBgn0087021
    Locus tag
    Dmel_CG7242
    See related
    AllianceGenome:FB:FBgn0087021
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD37196; cal2; Cal2; CG7242; Dmel\CG7242; dmSpc25R; l(3)87Da; l(3)A34-1; l(3)A46-1; l(3)c00064; l(3)S3; Mitch; S3; spc25
    Summary
    Involved in meiotic metaphase chromosome alignment; meiotic spindle organization; and mitotic metaphase chromosome alignment. Located in kinetochore. Part of Ndc80 complex. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spc25 in Genome Data Viewer
    Location:
    87D5-87D5; 3-53 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12961745..12963249)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8787467..8788971)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene beaten path Vb Neighboring gene long non-coding RNA:CR44236 Neighboring gene granny smith Neighboring gene Cytochrome P450 304a1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel mutation in the N-terminal domain of Drosophila BubR1 affects the spindle assembly checkpoint function of BubR1. Duranteau M, et al. Biol Open, 2016 Nov 15. PMID 27742609, Free PMC Article
    2. Mutations in the Drosophila rough deal gene affecting RZZ kinetochore function. Menant A, et al. Biol Cell, 2020 Oct. PMID 32602944
    3. Transgenerational propagation and quantitative maintenance of paternal centromeres depends on Cid/Cenp-A presence in Drosophila sperm. Raychaudhuri N, et al. PLoS Biol, 2012. PMID 23300376, Free PMC Article
    4. RZZ and Mad1 dynamics in Drosophila mitosis. Défachelles L, et al. Chromosome Res, 2015 Jun. PMID 25772408, Free PMC Article
    5. A mitotic role for Mad1 beyond the spindle checkpoint. Emre D, et al. J Cell Sci, 2011 May 15. PMID 21511728

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ndc80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ndc80 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Spc25
    Names
    CG7242-PA
    Spc25-PA
    chromosome alignment defect 2
    lethal (3) 87Da
    lethal (3) c00064
    mitch
    mitotic chaos

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12961745..12963249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141982.3 → NP_650239.1  Spc25 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650239.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3V7
      Related
      FBpp0082158
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3V7.1 Q9V3V7

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