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    path pathetic [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39106, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pathprovided by FlyBase
    Official Full Name
    patheticprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036007
    Locus tag
    Dmel_CG3424
    See related
    AllianceGenome:FB:FBgn0036007
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.271; anon-WO0118547.370; CG3424; Dmel\CG3424; Path; Pathetic; pth
    Summary
    Enables amino acid transmembrane transporter activity. Involved in several processes, including amino acid transmembrane transport; neuron projection morphogenesis; and regulation of cell projection size. Located in several cellular components, including dendrite; endolysosome; and neuronal cell body. Is expressed in several structures, including anlage in statu nascendi; brain; epithelial cell; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See path in Genome Data Viewer
    Location:
    67B10-67B10; 3-29 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9494555..9505328, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9487655..9498428, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene antisense RNA:CR45874 Neighboring gene Ribosomal protein S9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functions of the SLC36 transporter Pathetic in growth control. Lin WY, et al. Fly (Austin), 2015. PMID 26735916, Free PMC Article
    2. Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. Harrison DA, et al. EMBO J, 1995 Jun 15. PMID 7796812, Free PMC Article
    3. The SLC36 transporter Pathetic is required for neural stem cell proliferation and for brain growth under nutrition restriction. Feng S, et al. Neural Dev, 2020 Aug 2. PMID 32741363, Free PMC Article
    4. Auditory circuit in the Drosophila brain. Lai JS, et al. Proc Natl Acad Sci U S A, 2012 Feb 14. PMID 22308412, Free PMC Article
    5. Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation. Heublein S, et al. Oncogene, 2010 Jul 15. PMID 20498635, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The SLC36 transporter Pathetic is required for neural stem cell proliferation and for brain growth under nutrition restriction.
      Title: The SLC36 transporter Pathetic is required for neural stem cell proliferation and for brain growth under nutrition restriction.
    2. Path is a nutrient sensor with widespread function in Drosophila.
      Title: Functions of the SLC36 transporter Pathetic in growth control.
    3. mutation of pathetic impinges on nutrient responses and protein homeostasis specifically in neurons with large dendrite arbors but not in other cells.
      Title: The SLC36 transporter Pathetic is required for extreme dendrite growth in Drosophila sensory neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell projection size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endolysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pathetic
    Names
    CG3424-PA
    CG3424-PD
    CG3424-PE
    path-PA
    path-PD
    path-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9494555..9505328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140070.3 → NP_648327.1  pathetic, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648327.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VT04
      Related
      FBpp0076156
      Conserved Domains (2) summary
      COG0814
      Location:67 → 445
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:56 → 456
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_001274705.1 → NP_001261634.1  pathetic, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261634.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VT04
      Conserved Domains (2) summary
      COG0814
      Location:67 → 445
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:56 → 456
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. NM_168349.2 → NP_729505.2  pathetic, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729505.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VT03
      Conserved Domains (2) summary
      COG0814
      Location:54 → 432
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:43 → 443
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VT03 Q9VT03
    Q9VT04.1 Q9VT04

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