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    knl-2 Kinetochore null protein 2 [ Caenorhabditis elegans ]

    Gene ID: 172350, updated on 9-Dec-2024

    Summary

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    Official Symbol
    knl-2
    Official Full Name
    Kinetochore null protein 2
    Primary source
    WormBase:WBGene00019432
    Locus tag
    CELE_K06A5.4
    See related
    AllianceGenome:WB:WBGene00019432
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in cell division; chromosome segregation; and meiotic cell cycle. Located in kinetochore and nucleus. Orthologous to human MIS18BP1 (MIS18 binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See knl-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (6460878..6464286)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Ras-related protein Rab-10 Neighboring gene ncRNA Neighboring gene Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Neighboring gene Major sperm protein Neighboring gene DUF389 domain membrane protein Neighboring gene M-phase inducer phosphatase cdc-25.1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transgenerational inheritance of centromere identity requires the CENP-A N-terminal tail in the C. elegans maternal germ line. Prosée RF, et al. PLoS Biol, 2021 Jul. PMID 34228701, Free PMC Article
    2. The N-terminal tail of C. elegans CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly. de Groot C, et al. Mol Biol Cell, 2021 Jun 1. PMID 33852350, Free PMC Article
    3. Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin. Maddox PS, et al. J Cell Biol, 2007 Mar 12. PMID 17339379, Free PMC Article
    4. Mitotic chromosome condensation requires phosphorylation of the centromeric protein KNL-2 in C. elegans. Wenda JM, et al. J Cell Sci, 2021 Dec 1. PMID 34734636, Free PMC Article
    5. Initiation of Meiotic Development Is Controlled by Three Post-transcriptional Pathways in Caenorhabditis elegans. Mohammad A, et al. Genetics, 2018 Aug. PMID 29941619, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitotic chromosome condensation requires phosphorylation of the centromeric protein KNL-2 in C. elegans.
      Title: Mitotic chromosome condensation requires phosphorylation of the centromeric protein KNL-2 in C. elegans.
    2. The N-terminal tail of C. elegans CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly.
      Title: The N-terminal tail of C. elegans CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly.
    3. RbAp46/48LIN-53 localizes to the centromere during metaphase in a CENP-A (HCP-3)- and M18BP1KNL-2-dependent manner, suggesting CENP-A loading may occur before anaphase.
      Title: RbAp46/48(LIN-53) Is Required for Holocentromere Assembly in Caenorhabditis elegans.
    4. KNL-2 is specifically required for CENP-A incorporation into chromatin.
      Title: Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kinetochore null protein 2
    NP_001367697.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6460878..6464286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380547.1 → NP_001367697.1  Kinetochore null protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44548
      Conserved Domains (3) summary
      PTZ00121
      Location:394 → 729
      PTZ00121; MAEBL; Provisional
      PRK12678
      Location:339 → 509
      PRK12678; transcription termination factor Rho; Provisional
      pfam09133
      Location:20 → 108
      SANTA; SANTA (SANT Associated)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44548.2

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