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    Rnpepl1 arginyl aminopeptidase (aminopeptidase B)-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 108657, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rnpepl1provided by MGI
    Official Full Name
    arginyl aminopeptidase (aminopeptidase B)-like 1provided by MGI
    Primary source
    MGI:MGI:1914170
    See related
    Ensembl:ENSMUSG00000026269 AllianceGenome:MGI:1914170
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110014H17Rik
    Summary
    Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Is expressed in central nervous system and retina. Orthologous to human RNPEPL1 (arginyl aminopeptidase like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 84.6), duodenum adult (RPKM 84.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnpepl1 in Genome Data Viewer
    Location:
    1 D; 1 46.6 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (92837697..92848307)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (92910377..92920585)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and MYND domain containing 1 Neighboring gene predicted gene, 57577 Neighboring gene RIKEN cDNA 5033417F24 gene Neighboring gene dual specificity phosphatase 28 Neighboring gene STARR-seq mESC enhancer starr_01722 Neighboring gene RIKEN cDNA 9430060I03 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:94830898-94831081 Neighboring gene STARR-positive B cell enhancer ABC_E4335 Neighboring gene calpain 10 Neighboring gene G protein-coupled receptor 35

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables initiator methionyl aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloaminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metalloaminopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    aminopeptidase RNPEPL1
    Names
    arginyl aminopeptidase-like 1
    methionyl aminopeptidase
    NP_852070.3
    XP_011246195.1
    XP_011246196.1
    XP_011246197.1
    XP_030111019.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181405.4 → NP_852070.3  aminopeptidase RNPEPL1

      Status: VALIDATED

      Source sequence(s)
      AC119846, AV008848, AW488182, BQ559332, CA315475, CA750931, CX213696, CX218581
      Consensus CDS
      CCDS15180.2
      UniProtKB/Swiss-Prot
      G5E872
      Related
      ENSMUSP00000027487.9, ENSMUST00000027487.15
      Conserved Domains (2) summary
      cd09599
      Location:29 → 507
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      pfam09127
      Location:524 → 668
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      92837697..92848307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247893.4 → XP_011246195.1  aminopeptidase RNPEPL1 isoform X1

      Conserved Domains (2) summary
      cd09599
      Location:29 → 469
      M1_LTA4H; Peptidase M1 family including Leukotriene A4 hydrolase catalytic domain
      pfam09127
      Location:517 → 630
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

    2. XM_011247895.4 → XP_011246197.1  aminopeptidase RNPEPL1 isoform X3

      See identical proteins and their annotated locations for XP_011246197.1

      UniProtKB/TrEMBL
      Q8K2C3
      Conserved Domains (2) summary
      pfam09127
      Location:329 → 442
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
      cl14813
      Location:1 → 281
      GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    3. XM_030255159.2 → XP_030111019.1  aminopeptidase RNPEPL1 isoform X4

      UniProtKB/TrEMBL
      Q8K2C3
      Conserved Domains (2) summary
      pfam09127
      Location:291 → 404
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
      cl14813
      Location:1 → 243
      GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    4. XM_011247894.3 → XP_011246196.1  aminopeptidase RNPEPL1 isoform X2

      UniProtKB/TrEMBL
      Q8K2C3
      Conserved Domains (2) summary
      cd09599
      Location:18 → 358
      M1_LTA4H; Peptidase M1 family including Leukotriene A4 hydrolase catalytic domain
      pfam09127
      Location:406 → 519
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5E872.2 GenPept UniProtKB/Swiss-Prot:G5E872

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