U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Arhgap22 Rho GTPase activating protein 22 [ Mus musculus (house mouse) ]

    Gene ID: 239027, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arhgap22provided by MGI
    Official Full Name
    Rho GTPase activating protein 22provided by MGI
    Primary source
    MGI:MGI:2443418
    See related
    Ensembl:ENSMUSG00000063506 AllianceGenome:MGI:2443418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RHOGAP2; p68RacGAP; B230341L19Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction and regulation of postsynapse organization. Predicted to be located in cytoplasm and nucleus. Predicted to be active in glutamatergic synapse. Orthologous to human ARHGAP22 (Rho GTPase activating protein 22). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 3.9), ovary adult (RPKM 3.8) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Arhgap22 in Genome Data Viewer
    Location:
    14 B; 14 20.15 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (32935952..33091893)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (33213994..33369936)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36348 Neighboring gene predicted gene, 25498 Neighboring gene predicted pseudogene 6340 Neighboring gene predicted gene, 41130 Neighboring gene STARR-seq mESC enhancer starr_36351 Neighboring gene mitogen-activated protein kinase 8 Neighboring gene STARR-seq mESC enhancer starr_36353 Neighboring gene FERM and PDZ domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC47316

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of postsynapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 22
    Names
    rho-type GTPase-activating protein 22

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153800.4NP_722495.3  rho GTPase-activating protein 22

      See identical proteins and their annotated locations for NP_722495.3

      Status: VALIDATED

      Source sequence(s)
      AK046097, AK078218, BB370610
      Consensus CDS
      CCDS26926.2
      UniProtKB/Swiss-Prot
      Q6QHH6, Q8BL80, Q8BVH4, Q8CHY5
      Related
      ENSMUSP00000107587.3, ENSMUST00000111956.9
      Conserved Domains (4) summary
      cd04390
      Location:157355
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam07111
      Location:602683
      HCR; Alpha helical coiled-coil rod protein (HCR)
      pfam09726
      Location:493683
      Macoilin; Macoilin family
      cl17171
      Location:42157
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      32935952..33091893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518956.5XP_006519019.1  rho GTPase-activating protein 22 isoform X3

      Conserved Domains (3) summary
      cd04390
      Location:173371
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      TIGR02168
      Location:610698
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:42157
      PH-like; Pleckstrin homology-like domain
    2. XM_011245053.4XP_011243355.1  rho GTPase-activating protein 22 isoform X5

      See identical proteins and their annotated locations for XP_011243355.1

      UniProtKB/Swiss-Prot
      Q6QHH6, Q8BL80, Q8BVH4, Q8CHY5
      Conserved Domains (4) summary
      cd04390
      Location:157355
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam07111
      Location:602683
      HCR; Alpha helical coiled-coil rod protein (HCR)
      pfam09726
      Location:493683
      Macoilin; Macoilin family
      cl17171
      Location:42157
      PH-like; Pleckstrin homology-like domain
    3. XM_036158588.1XP_036014481.1  rho GTPase-activating protein 22 isoform X3

      Conserved Domains (3) summary
      cd04390
      Location:173371
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      TIGR02168
      Location:610698
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:42157
      PH-like; Pleckstrin homology-like domain
    4. XM_006518957.5XP_006519020.1  rho GTPase-activating protein 22 isoform X4

      Conserved Domains (4) summary
      cd04390
      Location:167365
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam07111
      Location:612693
      HCR; Alpha helical coiled-coil rod protein (HCR)
      pfam09726
      Location:503693
      Macoilin; Macoilin family
      cl17171
      Location:36151
      PH-like; Pleckstrin homology-like domain
    5. XM_030247787.2XP_030103647.1  rho GTPase-activating protein 22 isoform X6

      Conserved Domains (4) summary
      cd04390
      Location:151349
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam07111
      Location:596677
      HCR; Alpha helical coiled-coil rod protein (HCR)
      pfam09726
      Location:487677
      Macoilin; Macoilin family
      cl17171
      Location:36151
      PH-like; Pleckstrin homology-like domain
    6. XM_006518954.5XP_006519017.1  rho GTPase-activating protein 22 isoform X1

      Conserved Domains (4) summary
      cd04390
      Location:193391
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam07111
      Location:638719
      HCR; Alpha helical coiled-coil rod protein (HCR)
      pfam09726
      Location:529719
      Macoilin; Macoilin family
      cl17171
      Location:62177
      PH-like; Pleckstrin homology-like domain
    7. XM_017316004.3XP_017171493.1  rho GTPase-activating protein 22 isoform X2

      Conserved Domains (4) summary
      cd04390
      Location:177375
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam07111
      Location:622703
      HCR; Alpha helical coiled-coil rod protein (HCR)
      pfam09726
      Location:513703
      Macoilin; Macoilin family
      cl17171
      Location:62177
      PH-like; Pleckstrin homology-like domain
    8. XM_017316006.3XP_017171495.1  rho GTPase-activating protein 22 isoform X7

      Conserved Domains (4) summary
      cd04390
      Location:134332
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam07111
      Location:579660
      HCR; Alpha helical coiled-coil rod protein (HCR)
      pfam09726
      Location:470660
      Macoilin; Macoilin family
      cl17171
      Location:62147
      PH-like; Pleckstrin homology-like domain
    9. XM_006518959.3XP_006519022.1  rho GTPase-activating protein 22 isoform X8

      UniProtKB/TrEMBL
      D3Z1Y5
      Conserved Domains (4) summary
      cd04390
      Location:77275
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam07111
      Location:522603
      HCR; Alpha helical coiled-coil rod protein (HCR)
      pfam09726
      Location:413603
      Macoilin; Macoilin family
      cl17171
      Location:1861
      PH-like; Pleckstrin homology-like domain
    10. XM_006518961.5XP_006519024.1  rho GTPase-activating protein 22 isoform X10

      UniProtKB/TrEMBL
      D3Z1Y5
      Related
      ENSMUSP00000107586.2, ENSMUST00000111955.2
      Conserved Domains (4) summary
      cd04390
      Location:61259
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam07111
      Location:506587
      HCR; Alpha helical coiled-coil rod protein (HCR)
      pfam09726
      Location:397587
      Macoilin; Macoilin family
      cl17171
      Location:1861
      PH-like; Pleckstrin homology-like domain
    11. XM_036158589.1XP_036014482.1  rho GTPase-activating protein 22 isoform X13

      UniProtKB/TrEMBL
      D3Z1Y5
      Conserved Domains (2) summary
      cd04390
      Location:18216
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      TIGR02168
      Location:455543
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    12. XM_006518960.4XP_006519023.1  rho GTPase-activating protein 22 isoform X9

      UniProtKB/TrEMBL
      D3Z1Y5
      Conserved Domains (4) summary
      cd04390
      Location:77275
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam07111
      Location:522603
      HCR; Alpha helical coiled-coil rod protein (HCR)
      pfam09726
      Location:413603
      Macoilin; Macoilin family
      cl17171
      Location:1861
      PH-like; Pleckstrin homology-like domain
    13. XM_006518962.4XP_006519025.1  rho GTPase-activating protein 22 isoform X11

      UniProtKB/TrEMBL
      D3Z1Y5
      Related
      ENSMUST00000137590.8
      Conserved Domains (4) summary
      cd04390
      Location:61259
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam07111
      Location:506587
      HCR; Alpha helical coiled-coil rod protein (HCR)
      pfam09726
      Location:397587
      Macoilin; Macoilin family
      cl17171
      Location:1861
      PH-like; Pleckstrin homology-like domain
    14. XM_006518963.5XP_006519026.1  rho GTPase-activating protein 22 isoform X12

      UniProtKB/TrEMBL
      D3Z1Y5
      Conserved Domains (3) summary
      cd04390
      Location:33231
      RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
      pfam07111
      Location:478559
      HCR; Alpha helical coiled-coil rod protein (HCR)
      pfam09726
      Location:369559
      Macoilin; Macoilin family
    15. XM_011245054.1XP_011243356.1  rho GTPase-activating protein 22 isoform X14

      Conserved Domains (3) summary
      TIGR02168
      Location:286374
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09726
      Location:185375
      Macoilin; Macoilin family
      cl02570
      Location:147
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    RNA

    1. XR_004938394.1 RNA Sequence

    2. XR_003950847.2 RNA Sequence

    3. XR_004938393.1 RNA Sequence