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    Prrg1 proline rich Gla (G-carboxyglutamic acid) 1 [ Mus musculus (house mouse) ]

    Gene ID: 546336, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Prrg1provided by MGI
    Official Full Name
    proline rich Gla (G-carboxyglutamic acid) 1provided by MGI
    Primary source
    MGI:MGI:1917364
    See related
    Ensembl:ENSMUSG00000047996 AllianceGenome:MGI:1917364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010007L08Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation. Predicted to be active in extracellular space. Orthologous to human PRRG1 (proline rich and Gla domain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 6.0), limb E14.5 (RPKM 2.8) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prrg1 in Genome Data Viewer
    Location:
    X B; X 38.34 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (77493216..77627539, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (78449610..78583914, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47425 Neighboring gene suppressor of zeste 12 homolog pseudogene Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47426 Neighboring gene histone H3.3-like Neighboring gene ring finger protein 41 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane gamma-carboxyglutamic acid protein 1
    Names
    ortholog of proline rich Gla (G-carboxyglutamic acid) 1 PRRG1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164275.2 → NP_001157747.1  transmembrane gamma-carboxyglutamic acid protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK135895, AL672300, BX284111, CF915689, CJ052035, CX242928
      Consensus CDS
      CCDS53121.1
      UniProtKB/TrEMBL
      A2BFE8
      Related
      ENSMUSP00000136713.2, ENSMUST00000177904.8
      Conserved Domains (2) summary
      smart00069
      Location:2 → 65
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      pfam15471
      Location:128 → 206
      TMEM171; Transmembrane protein family 171

    2. NM_001289683.1 → NP_001276612.1  transmembrane gamma-carboxyglutamic acid protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK135895, AL672300, BX284111, CF915689, CX242928
      Consensus CDS
      CCDS53121.1
      UniProtKB/TrEMBL
      A2BFE8
      Related
      ENSMUSP00000109659.2, ENSMUST00000114025.8
      Conserved Domains (2) summary
      smart00069
      Location:2 → 65
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      pfam15471
      Location:128 → 206
      TMEM171; Transmembrane protein family 171

    3. NM_027322.2 → NP_081598.1  transmembrane gamma-carboxyglutamic acid protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK135895, AL672300, BX284111, CF915689, CJ052035, CX242928
      Consensus CDS
      CCDS53121.1
      UniProtKB/TrEMBL
      A2BFE8
      Related
      ENSMUSP00000109658.3, ENSMUST00000114024.9
      Conserved Domains (2) summary
      smart00069
      Location:2 → 65
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      pfam15471
      Location:128 → 206
      TMEM171; Transmembrane protein family 171

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      77493216..77627539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162025.1 → XP_036017918.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

      Conserved Domains (1) summary
      smart00069
      Location:24 → 87
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    2. XM_006528143.4 → XP_006528206.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

      Conserved Domains (1) summary
      smart00069
      Location:24 → 87
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    3. XM_036162022.1 → XP_036017915.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X1

      Conserved Domains (1) summary
      smart00069
      Location:76 → 139
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    4. XM_011247638.3 → XP_011245940.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X6

      UniProtKB/TrEMBL
      A2BFE8
      Conserved Domains (2) summary
      smart00069
      Location:2 → 65
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      pfam15471
      Location:128 → 206
      TMEM171; Transmembrane protein family 171

    5. XM_011247634.3 → XP_011245936.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

      Conserved Domains (1) summary
      smart00069
      Location:24 → 87
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    6. XM_006528144.4 → XP_006528207.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

      Conserved Domains (1) summary
      smart00069
      Location:24 → 87
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    7. XM_011247633.4 → XP_011245935.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

      Conserved Domains (1) summary
      smart00069
      Location:24 → 87
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    8. XM_011247637.3 → XP_011245939.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X6

      UniProtKB/TrEMBL
      A2BFE8
      Conserved Domains (2) summary
      smart00069
      Location:2 → 65
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      pfam15471
      Location:128 → 206
      TMEM171; Transmembrane protein family 171

    9. XM_011247632.3 → XP_011245934.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

      Conserved Domains (1) summary
      smart00069
      Location:24 → 87
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    10. XM_017318551.3 → XP_017174040.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X6

      UniProtKB/TrEMBL
      A2BFE8
      Conserved Domains (2) summary
      smart00069
      Location:2 → 65
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      pfam15471
      Location:128 → 206
      TMEM171; Transmembrane protein family 171

    11. XM_006528142.5 → XP_006528205.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

      Conserved Domains (1) summary
      smart00069
      Location:24 → 87
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    12. XM_030251387.2 → XP_030107247.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X6

      UniProtKB/TrEMBL
      A2BFE8
      Conserved Domains (2) summary
      smart00069
      Location:2 → 65
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      pfam15471
      Location:128 → 206
      TMEM171; Transmembrane protein family 171

    13. XM_011247635.2 → XP_011245937.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

      Conserved Domains (1) summary
      smart00069
      Location:24 → 87
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    14. XM_036162024.1 → XP_036017917.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X4

      Conserved Domains (1) summary
      smart00069
      Location:39 → 102
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    15. XM_011247631.3 → XP_011245933.2  transmembrane gamma-carboxyglutamic acid protein 1 isoform X3

      Conserved Domains (2) summary
      smart00069
      Location:54 → 117
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      pfam15471
      Location:180 → 258
      TMEM171; Transmembrane protein family 171

    16. XM_036162023.1 → XP_036017916.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X2

      Conserved Domains (1) summary
      smart00069
      Location:41 → 104
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    17. XM_036162026.1 → XP_036017919.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X7

      Conserved Domains (1) summary
      smart00069
      Location:54 → 109
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    Nucleotide Protein Strain
    Heading Accession and Version

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