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    ROMO1 reactive oxygen species modulator 1 [ Homo sapiens (human) ]

    Gene ID: 140823, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ROMO1provided by HGNC
    Official Full Name
    reactive oxygen species modulator 1provided by HGNC
    Primary source
    HGNC:HGNC:16185
    See related
    Ensembl:ENSG00000125995 MIM:618894; AllianceGenome:HGNC:16185
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MTGM; MTGMP; C20orf52; bA353C18.2
    Summary
    The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014]
    Expression
    Ubiquitous expression in colon (RPKM 37.6), kidney (RPKM 33.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ROMO1 in Genome Data Viewer
    Location:
    20q11.22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (35699405..35700980)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (37420181..37421955)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (34287327..34288902)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene copine 1 Neighboring gene RNA binding motif protein 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17790 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34251645-34252150 Neighboring gene Sharpr-MPRA regulatory region 3991 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34252655-34253159 Neighboring gene NFS1 cysteine desulfurase Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34286841-34287500 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34287501-34288160 Neighboring gene RNA binding motif protein 39 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17795 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34330085-34330770 Neighboring gene ribosome production factor 2 homolog pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Romo1 is associated with ROS production and cellular growth in human gliomas. Yu MO, et al. J Neurooncol, 2015 Jan. PMID 25193023
    2. Romo1 is a mitochondrial nonselective cation channel with viroporin-like characteristics. Lee GY, et al. J Cell Biol, 2018 Jun 4. PMID 29545371, Free PMC Article
    3. Serum Romo1 is significantly associated with disease severity in patients with obstructive sleep apnea syndrome. Ye L, et al. Sleep Breath, 2018 Sep. PMID 29302924
    4. Reactive oxygen species modulator 1 (Romo1) as a novel diagnostic marker for lung cancer-related malignant effusion. Lee SH, et al. Medicine (Baltimore), 2017 Jan. PMID 28121949, Free PMC Article
    5. Reactive Oxygen Species Modulator 1 (Romo1) Predicts Poor Outcomes in Advanced Non-small Cell Lung Cancer Patients Treated with Platinum-Based Chemotherapy. Lee SH, et al. Cancer Res Treat, 2017 Jan. PMID 27188201, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The effects of ROMO1 on cervical cancer progression.
      Title: The effects of ROMO1 on cervical cancer progression.
    2. Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer.
      Title: Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer.
    3. Network models of prostate cancer immune microenvironments identify ROMO1 as heterogeneity and prognostic marker.
      Title: Network models of prostate cancer immune microenvironments identify ROMO1 as heterogeneity and prognostic marker.
    4. Overexpression of reactive oxygen species modulator 1 is associated with advanced grades of bladder cancer.
      Title: Overexpression of reactive oxygen species modulator 1 is associated with advanced grades of bladder cancer.
    5. The C allele of the reactive oxygen species modulator 1 (ROMO1) polymorphism rs6060566 is a biomarker predicting coronary artery stenosis in Slovenian subjects with type 2 diabetes mellitus.
      Title: The C allele of the reactive oxygen species modulator 1 (ROMO1) polymorphism rs6060566 is a biomarker predicting coronary artery stenosis in Slovenian subjects with type 2 diabetes mellitus.
    6. Overexpression of ROMO1 and OMA1 are Potentially Biomarkers and Predict Unfavorable Prognosis in Gastric Cancer.
      Title: Overexpression of ROMO1 and OMA1 are Potentially Biomarkers and Predict Unfavorable Prognosis in Gastric Cancer.
    7. Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis.
      Title: Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis.
    8. Reactive oxygen species modulator 1 expression predicts lymph node metastasis and survival in early-stage non-small cell lung cancer.
      Title: Reactive oxygen species modulator 1 expression predicts lymph node metastasis and survival in early-stage non-small cell lung cancer.
    9. Clinical value of combined detection of reactive oxygen species modulator 1 and adenosine deaminase in pleural effusion in the identification of NSCLC associated malignant pleural effusion.
      Title: Clinical value of combined detection of reactive oxygen species modulator 1 and adenosine deaminase in pleural effusion in the identification of NSCLC associated malignant pleural effusion.
    10. serum Romo1 levels increase in COPD patients and these levels are associated with lung function, inflammation, and oxidative stress in COPD.
      Title: Increased Serum Romo1 Was Correlated with Lung Function, Inflammation, and Oxidative Stress in Chronic Obstructive Pulmonary Disease.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC111180

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables monoatomic cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytolysis by host of symbiont cells IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular protein transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in killing of cells of another organism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in killing of cells of another organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of reactive oxygen species metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replicative senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TIM23 mitochondrial import inner membrane translocase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TIM23 mitochondrial import inner membrane translocase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    reactive oxygen species modulator 1
    Names
    PCM19
    ROS modulator 1
    epididymis tissue protein Li 175
    glyrichin
    mitochondrial targeting GXXXG protein
    mitochondrial targeting GxxxG motif protein
    protein MGR2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080748.3 → NP_542786.1  reactive oxygen species modulator 1

      See identical proteins and their annotated locations for NP_542786.1

      Status: REVIEWED

      Source sequence(s)
      AK000548, BC105281
      Consensus CDS
      CCDS13264.1
      UniProtKB/Swiss-Prot
      A7M872, E1P5R9, E9KL28, P60602, Q3MHD5, Q5QP16, Q9CQ98, Q9H1N2
      Related
      ENSP00000363190.3, ENST00000374077.8
      Conserved Domains (1) summary
      pfam10247
      Location:14 → 79
      Romo1; Reactive mitochondrial oxygen species modulator 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      35699405..35700980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027678.2 → XP_016883167.1  reactive oxygen species modulator 1 isoform X1

      UniProtKB/Swiss-Prot
      A7M872, E1P5R9, E9KL28, P60602, Q3MHD5, Q5QP16, Q9CQ98, Q9H1N2
      Related
      ENSP00000363191.1, ENST00000374078.5
      Conserved Domains (1) summary
      pfam10247
      Location:14 → 79
      Romo1; Reactive mitochondrial oxygen species modulator 1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      37420181..37421955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323022.1 → XP_054178997.1  reactive oxygen species modulator 1 isoform X1

      UniProtKB/Swiss-Prot
      A7M872, E1P5R9, E9KL28, P60602, Q3MHD5, Q5QP16, Q9CQ98, Q9H1N2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60602.1 GenPept UniProtKB/Swiss-Prot:P60602

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