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    Thnsl2 threonine synthase-like 2 (bacterial) [ Mus musculus (house mouse) ]

    Gene ID: 232078, updated on 9-Dec-2024

    Summary

    Official Symbol
    Thnsl2provided by MGI
    Official Full Name
    threonine synthase-like 2 (bacterial)provided by MGI
    Primary source
    MGI:MGI:3041254
    See related
    Ensembl:ENSMUSG00000054474 AllianceGenome:MGI:3041254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TSH2
    Summary
    Enables pyridoxal phosphate binding activity and serine binding activity. Involved in 2-oxobutyrate biosynthetic process; dephosphorylation; and serine family amino acid catabolic process. Is expressed in renal calyx. Orthologous to human THNSL2 (threonine synthase like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 87.1), placenta adult (RPKM 25.3) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Thnsl2 in Genome Data Viewer
    Location:
    6 C1; 6 32.14 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71105150..71121364, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71128166..71144380, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16251 Neighboring gene predicted gene, 38826 Neighboring gene ribosomal protein L34, pseudogene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:71093854-71094037 Neighboring gene STARR-seq mESC enhancer starr_16253 Neighboring gene predicted gene, 30391 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:71104939-71105048 Neighboring gene predicted gene, 38827

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    threonine synthase-like 2
    NP_001029101.1
    NP_848500.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033929.2NP_001029101.1  threonine synthase-like 2

      See identical proteins and their annotated locations for NP_001029101.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI156509, AK165463, BQ042728, CX223060
      Consensus CDS
      CCDS20225.1
      UniProtKB/Swiss-Prot
      Q80W22, Q8R135
      Related
      ENSMUSP00000124423.2, ENSMUST00000160918.8
      Conserved Domains (2) summary
      cd01560
      Location:2463
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      PRK09225
      Location:1453
      PRK09225; threonine synthase; Validated
    2. NM_178413.5NP_848500.3  threonine synthase-like 2

      See identical proteins and their annotated locations for NP_848500.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154003, AI156509, AK165463, BQ042728, CX223060
      Consensus CDS
      CCDS20225.1
      UniProtKB/Swiss-Prot
      Q80W22, Q8R135
      Related
      ENSMUSP00000073861.8, ENSMUST00000074241.9
      Conserved Domains (2) summary
      cd01560
      Location:2463
      Thr-synth_2; Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria, ...
      PRK09225
      Location:1453
      PRK09225; threonine synthase; Validated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      71105150..71121364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)