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    GPR61 G protein-coupled receptor 61 [ Homo sapiens (human) ]

    Gene ID: 83873, updated on 27-Nov-2024

    Summary

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    Official Symbol
    GPR61provided by HGNC
    Official Full Name
    G protein-coupled receptor 61provided by HGNC
    Primary source
    HGNC:HGNC:13300
    See related
    Ensembl:ENSG00000156097 MIM:606916; AllianceGenome:HGNC:13300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BALGR; GPCR3
    Summary
    This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 1.2), thyroid (RPKM 0.5) and 3 other tissues See more
    Orthologs
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    Genomic context

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    See GPR61 in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (109539872..109547260)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (109572595..109579983)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110082494..110089882)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1155 Neighboring gene uncharacterized LOC105378893 Neighboring gene adhesion molecule with Ig like domain 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1443 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:110073289-110073457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110082007-110082508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110082509-110083008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110086313-110086851 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:110089013-110089249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1445 Neighboring gene G protein subunit alpha i3 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:110106789-110107398 Neighboring gene RNA, U6 small nuclear variant sequence with SNRPE pseudogene sequence Neighboring gene microRNA 197

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain. Cikos S, et al. Biochim Biophys Acta, 2001 Oct 31. PMID 11690637
    2. A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors. Conner AC, et al. Mol Pharmacol, 2005 Jan. PMID 15615699
    3. The N-terminal domain of GPR61, an orphan G-protein-coupled receptor, is essential for its constitutive activity. Toyooka M, et al. J Neurosci Res, 2009 May 1. PMID 19025769
    4. Identification of four novel human G protein-coupled receptors expressed in the brain. Lee DK, et al. Brain Res Mol Brain Res, 2001 Jan 31. PMID 11165367
    5. Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT(2) receptor reciprocally modulate their signaling functions. Oishi A, et al. Sci Rep, 2017 Aug 21. PMID 28827538, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Collectively, these data show that GPR61, GPR62 and GPR135 are unable to bind melatonin, but show a reciprocal regulatory interaction with MT2 receptors.
      Title: Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT(2) receptor reciprocally modulate their signaling functions.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
    3. We conclude that the N-terminal domain of GPR61 is required for maintaining its constitutive activity and functions as a tethered intramolecular ligand.
      Title: The N-terminal domain of GPR61, an orphan G-protein-coupled receptor, is essential for its constitutive activity.
    4. maps to chromosome 1, is widely expressed, with expression highest in the brain areas associated with cognition, learning, and memory.
      Title: Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain.
    5. Modeling rationalizes the effects of transmembrane proline mutants previously reported for another family of GPCR.
      Title: A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arrestin family protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein coupled receptor 61
    Names
    biogenic amine receptor-like G-protein coupled receptor
    biogenic amine receptor-like GPCR
    probable G-protein coupled receptor 61

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032758.2 RefSeqGene

      Range
      5001..12389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393907.1 → NP_001380836.1  G-protein coupled receptor 61

      Status: REVIEWED

      Source sequence(s)
      AL355145, AL355310
      Consensus CDS
      CCDS801.1
      UniProtKB/Swiss-Prot
      A8K1W2, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
      UniProtKB/TrEMBL
      G4XH66
      Related
      ENSP00000432456.1, ENST00000527748.5
      Conserved Domains (1) summary
      cd15220
      Location:44 → 352
      7tmA_GPR61_GPR62-like; G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_031936.6 → NP_114142.3  G-protein coupled receptor 61

      See identical proteins and their annotated locations for NP_114142.3

      Status: REVIEWED

      Source sequence(s)
      AF258342, AL355310, DA176879
      Consensus CDS
      CCDS801.1
      UniProtKB/Swiss-Prot
      A8K1W2, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
      UniProtKB/TrEMBL
      G4XH66
      Related
      ENSP00000385422.2, ENST00000404129.6
      Conserved Domains (1) summary
      cd15220
      Location:44 → 352
      7tmA_GPR61_GPR62-like; G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      109539872..109547260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431615.1 → XP_047287571.1  G-protein coupled receptor 61 isoform X1

      UniProtKB/Swiss-Prot
      A8K1W2, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
      UniProtKB/TrEMBL
      G4XH66

    2. XM_047431617.1 → XP_047287573.1  G-protein coupled receptor 61 isoform X1

      UniProtKB/Swiss-Prot
      A8K1W2, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
      UniProtKB/TrEMBL
      G4XH66
      Related
      ENSP00000433661.1, ENST00000469383.2

    3. XM_047431614.1 → XP_047287570.1  G-protein coupled receptor 61 isoform X1

      UniProtKB/Swiss-Prot
      A8K1W2, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
      UniProtKB/TrEMBL
      G4XH66

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      109572595..109579983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008486172.1 RNA Sequence

    2. XR_008486171.1 RNA Sequence

    3. XR_008486173.1 RNA Sequence

    4. XR_008486174.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BZJ8.2 GenPept UniProtKB/Swiss-Prot:Q9BZJ8

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