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    C1QTNF12 C1q and TNF related 12 [ Homo sapiens (human) ]

    Gene ID: 388581, updated on 10-Dec-2024

    Summary

    Official Symbol
    C1QTNF12provided by HGNC
    Official Full Name
    C1q and TNF related 12provided by HGNC
    Primary source
    HGNC:HGNC:32308
    See related
    Ensembl:ENSG00000184163 MIM:616593; AllianceGenome:HGNC:32308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C1QDC2; CTRP12; FAM132A
    Summary
    Predicted to enable hormone activity. Predicted to be involved in negative regulation of gluconeogenesis; positive regulation of D-glucose import; and positive regulation of insulin receptor signaling pathway. Predicted to act upstream of or within negative regulation of inflammatory response; positive regulation of cell communication; and regulation of glucose metabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in duodenum (RPKM 4.0), small intestine (RPKM 3.7) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See C1QTNF12 in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1242453..1247280, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (670953..676213, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1177833..1182102, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene stromal cell derived factor 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1167335-1168016 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1168017-1168698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1169483-1169984 Neighboring gene beta-1,3-galactosyltransferase 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1182045-1182826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1182827-1183607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14 Neighboring gene ubiquitin conjugating enzyme E2 J2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:1199775-1200974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1207366-1207874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1207875-1208381 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1208382-1208889 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 49 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 50 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1210080-1210718 Neighboring gene long intergenic non-protein coding RNA 1786 Neighboring gene sodium channel epithelial 1 subunit delta

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Clone Names

    • MGC105127

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    adipolin
    Names
    C1q and TNF related protein 12
    C1q and tumor necrosis factor related protein 12
    C1q domain containing 2
    C1q/TNF-related protein 12
    adipose-derived insulin-sensitizing factor
    complement C1q tumor necrosis factor-related protein 12
    family with sequence similarity 132 member A
    protein FAM132A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014980.3NP_001014980.1  adipolin precursor

      See identical proteins and their annotated locations for NP_001014980.1

      Status: VALIDATED

      Source sequence(s)
      BC089443
      Consensus CDS
      CCDS30554.1
      UniProtKB/Swiss-Prot
      Q5EBL5, Q5T7M4
      Related
      ENSP00000329137.2, ENST00000330388.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1242453..1247280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419982.1XP_047275938.1  adipolin isoform X5

    2. XM_011541437.2XP_011539739.1  adipolin isoform X4

    3. XM_011541436.3XP_011539738.1  adipolin isoform X3

    4. XM_011541435.3XP_011539737.1  adipolin isoform X2

    5. XM_024446907.2XP_024302675.1  adipolin isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      670953..676213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336500.1XP_054192475.1  adipolin isoform X5

    2. XM_054336499.1XP_054192474.1  adipolin isoform X4

    3. XM_054336498.1XP_054192473.1  adipolin isoform X3

    4. XM_054336497.1XP_054192472.1  adipolin isoform X2

    5. XM_054336496.1XP_054192471.1  adipolin isoform X1