STK25 serine/threonine kinase 25 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STK25provided by HGNC
Official Full Name: serine/threonine kinase 25provided by HGNC
Primary source: HGNC:HGNC:11404
See related: Ensembl:ENSG00000115694 MIM:602255; AllianceGenome:HGNC:11404
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SOK1; YSK1
Summary: This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Expression: Ubiquitous expression in brain (RPKM 17.8), thyroid (RPKM 17.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q37.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (241492670..241509572, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (241992007..242008899, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (242432085..242448987, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STK25: a viable therapeutic target for cancer treatments?
Title: STK25: a viable therapeutic target for cancer treatments?
STK25 inhibits PKA signaling by phosphorylating PRKAR1A.
Title: STK25 inhibits PKA signaling by phosphorylating PRKAR1A.
Downregulation of STK25 promotes autophagy via the Janus kinase 2/signal transducer and activator of transcription 3 pathway in colorectal cancer.
Title: Downregulation of STK25 promotes autophagy via the Janus kinase 2/signal transducer and activator of transcription 3 pathway in colorectal cancer.
Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3beta/Nrf2 pathway.
Title: Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway.
Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways.
Title: Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways.
Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease.
Title: Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease.
STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism.
Title: STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism.
Our results demonstrated that STK25 negatively regulates the proliferation and glycolysis via GOLPH3-dependent mTOR signaling. Accordingly, STK25 could be a potential therapeutic target for the treatment of CRC.
Title: STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer.
Loss of STK25 promotes YAP/TAZ activation and enhanced cellular proliferation, even under normally growth-suppressive conditions both in vitro and in vivo.
Title: Identification of the kinase STK25 as an upstream activator of LATS signaling.
hYSK1 blocks the p21(WAF1/Cip1) functions by direct interaction and inhibits the p16(INK4a) expression and induces MMP-2 expression by its regulations of SP-1 transcriptional activity under the hypoxia conditions.
Title: p21(WAF1/Cip1) Regulation by hYSK1 Activates SP-1 Transcription Factor and Increases MMP-2 Expression under Hypoxic Conditions.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-19287 (e-PCR)
- UniSTS:81441

RH47049 (e-PCR)
- UniSTS:33613

D10S16 (e-PCR)
- UniSTS:155756

D15S1477 (e-PCR)
- UniSTS:474482

STK25_9122 (e-PCR)
- UniSTS:468146

WI-15981 (e-PCR)
- UniSTS:76475

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi localization	IDA Inferred from Direct Assay more info	PubMed
involved_in Golgi reassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in establishment of Golgi localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to hydrogen peroxide	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress-activated MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase 25

Names: Ste20, yeast homolog; ste20-like kinase; ste20/oxidant stress response kinase 1; sterile 20/oxidant stress-response kinase 1

NP_001258906.1

EC 2.7.11.1

NP_001258907.1

EC 2.7.11.1

NP_001258908.1

EC 2.7.11.1

NP_001258909.1

EC 2.7.11.1

NP_001269234.1

EC 2.7.11.1

NP_001269235.1

EC 2.7.11.1

NP_001269236.1

EC 2.7.11.1

NP_001269237.1

EC 2.7.11.1

NP_006365.2

EC 2.7.11.1

XP_011508795.1

EC 2.7.11.1

XP_011508796.1

EC 2.7.11.1

XP_011508797.1

EC 2.7.11.1

XP_011508798.1

EC 2.7.11.1

XP_016858659.1

EC 2.7.11.1

XP_047298880.1

EC 2.7.11.1

XP_047298881.1

EC 2.7.11.1

XP_054196157.1

EC 2.7.11.1

XP_054196158.1

EC 2.7.11.1

XP_054196159.1

EC 2.7.11.1

XP_054196160.1

EC 2.7.11.1

XP_054196161.1

EC 2.7.11.1

XP_054196162.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271977.2 → NP_001258906.1 serine/threonine-protein kinase 25 isoform 1

See identical proteins and their annotated locations for NP_001258906.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 4 and 5 encode the same isoform (1).

Source sequence(s)

AC110299, BC007852, BC091505, HY315908

Consensus CDS

CCDS2549.1

UniProtKB/Swiss-Prot

A8K6Z3, A8K7D2, B7Z9K1, O00506, Q15522, Q5BJF1

UniProtKB/TrEMBL

A0A024R4B2, A0A0S2Z4Y9, Q96BA2

Related

ENSP00000325748.4, ENST00000316586.9

Conserved Domains (1) summary

cd06642
Location:15 → 291

STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)
NM_001271978.2 → NP_001258907.1 serine/threonine-protein kinase 25 isoform 1

See identical proteins and their annotated locations for NP_001258907.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).

Source sequence(s)

AC110299, BC015793, BU541010, HY315908

Consensus CDS

CCDS2549.1

UniProtKB/Swiss-Prot

A8K6Z3, A8K7D2, B7Z9K1, O00506, Q15522, Q5BJF1

UniProtKB/TrEMBL

A0A024R4B2, A0A0S2Z4Y9, Q96BA2

Related

ENSP00000385687.1, ENST00000401869.5

Conserved Domains (1) summary

cd06642
Location:15 → 291

STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)
NM_001271979.2 → NP_001258908.1 serine/threonine-protein kinase 25 isoform 2

See identical proteins and their annotated locations for NP_001258908.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. Variants 8 and 9 encode the same isoform (2).

Source sequence(s)

AC110299, AK092161, DC353271, HY315908

Consensus CDS

CCDS63200.1

UniProtKB/TrEMBL

A0A0S2Z4Y2, B3KRS6

Related

ENSP00000384444.3, ENST00000405883.7

Conserved Domains (1) summary

cl21453
Location:12 → 214

PKc_like; Protein Kinases, catalytic domain
NM_001271980.2 → NP_001258909.1 serine/threonine-protein kinase 25 isoform 2

See identical proteins and their annotated locations for NP_001258909.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. Variants 8 and 9 encode the same isoform (2).

Source sequence(s)

AC110299, AK291808, CB250694, HY315908

Consensus CDS

CCDS63200.1

UniProtKB/TrEMBL

A0A0S2Z4Y2, B3KRS6

Related

ENSP00000385541.1, ENST00000405585.5

Conserved Domains (1) summary

cl21453
Location:12 → 214

PKc_like; Protein Kinases, catalytic domain
NM_001282305.1 → NP_001269234.1 serine/threonine-protein kinase 25 isoform 3

See identical proteins and their annotated locations for NP_001269234.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate 5' exon structure and thus differs in the 5' UTR and 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2, 6, and 7 encode the same isoform (3).

Source sequence(s)

AC110299, AK303719, CB250694, DA624380, HY315908

Consensus CDS

CCDS63199.1

UniProtKB/TrEMBL

B4E185

Related

ENSP00000444886.1, ENST00000543554.5

Conserved Domains (1) summary

cl21453
Location:1 → 197

PKc_like; Protein Kinases, catalytic domain
NM_001282306.2 → NP_001269235.1 serine/threonine-protein kinase 25 isoform 4

See identical proteins and their annotated locations for NP_001269235.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (4) with a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC110299, AK301214, CB250694, DC353271, HY315908

UniProtKB/TrEMBL

B4DVS7, B4E185

Conserved Domains (2) summary

smart00220
Location:16 → 196

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:16 → 217

PKc_like; Protein Kinases, catalytic domain
NM_001282307.2 → NP_001269236.1 serine/threonine-protein kinase 25 isoform 3

See identical proteins and their annotated locations for NP_001269236.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an exon which contains a portion of the 5' UTR and 5' coding region including the start codon, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2, 6, and 7 encode the same isoform (3).

Source sequence(s)

AC110299, AK297374, BC007852, DC353271, HY315908

Consensus CDS

CCDS63199.1

UniProtKB/TrEMBL

B4E185

Related

ENSP00000446008.1, ENST00000535007.5

Conserved Domains (1) summary

cl21453
Location:1 → 197

PKc_like; Protein Kinases, catalytic domain
NM_001282308.2 → NP_001269237.1 serine/threonine-protein kinase 25 isoform 3

See identical proteins and their annotated locations for NP_001269237.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an exon which contains a portion of the 5' UTR and 5' coding region including the start codon, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2, 6, and 7 encode the same isoform (3).

Source sequence(s)

AC110299, AK315966, CB250694, HY315908

Consensus CDS

CCDS63199.1

UniProtKB/TrEMBL

B4E185

Conserved Domains (1) summary

cl21453
Location:1 → 197

PKc_like; Protein Kinases, catalytic domain
NM_006374.5 → NP_006365.2 serine/threonine-protein kinase 25 isoform 1

See identical proteins and their annotated locations for NP_006365.2

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).

Source sequence(s)

AC110299, BC007852, HY315908

Consensus CDS

CCDS2549.1

UniProtKB/Swiss-Prot

A8K6Z3, A8K7D2, B7Z9K1, O00506, Q15522, Q5BJF1

UniProtKB/TrEMBL

A0A024R4B2, A0A0S2Z4Y9, Q96BA2

Related

ENSP00000384162.3, ENST00000403346.7

Conserved Domains (1) summary

cd06642
Location:15 → 291

STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

241492670..241509572 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011510495.3 → XP_011508797.1 serine/threonine-protein kinase 25 isoform X3

See identical proteins and their annotated locations for XP_011508797.1

UniProtKB/TrEMBL

B4DVS7, B4E185

Conserved Domains (2) summary

smart00220
Location:16 → 196

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:16 → 217

PKc_like; Protein Kinases, catalytic domain
XM_047442925.1 → XP_047298881.1 serine/threonine-protein kinase 25 isoform X3

UniProtKB/TrEMBL

B4DVS7, B4E185
XM_011510494.3 → XP_011508796.1 serine/threonine-protein kinase 25 isoform X3

See identical proteins and their annotated locations for XP_011508796.1

UniProtKB/TrEMBL

B4DVS7, B4E185

Conserved Domains (2) summary

smart00220
Location:16 → 196

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:16 → 217

PKc_like; Protein Kinases, catalytic domain
XM_017003170.2 → XP_016858659.1 serine/threonine-protein kinase 25 isoform X3

UniProtKB/TrEMBL

B4DVS7, B4E185

Conserved Domains (2) summary

smart00220
Location:16 → 196

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:16 → 217

PKc_like; Protein Kinases, catalytic domain
XM_047442924.1 → XP_047298880.1 serine/threonine-protein kinase 25 isoform X2
XM_011510496.4 → XP_011508798.1 serine/threonine-protein kinase 25 isoform X4

Conserved Domains (2) summary

smart00220
Location:20 → 270

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06642
Location:15 → 291

STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)
XM_011510493.4 → XP_011508795.1 serine/threonine-protein kinase 25 isoform X1

UniProtKB/TrEMBL

Q96BA2

Conserved Domains (2) summary

smart00220
Location:20 → 270

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06642
Location:15 → 291

STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

241992007..242008899 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054340186.1 → XP_054196161.1 serine/threonine-protein kinase 25 isoform X3

UniProtKB/TrEMBL

B4DVS7, B4E185
XM_054340184.1 → XP_054196159.1 serine/threonine-protein kinase 25 isoform X3

UniProtKB/TrEMBL

B4DVS7, B4E185
XM_054340185.1 → XP_054196160.1 serine/threonine-protein kinase 25 isoform X3

UniProtKB/TrEMBL

B4DVS7, B4E185
XM_054340183.1 → XP_054196158.1 serine/threonine-protein kinase 25 isoform X2
XM_054340187.1 → XP_054196162.1 serine/threonine-protein kinase 25 isoform X4
XM_054340182.1 → XP_054196157.1 serine/threonine-protein kinase 25 isoform X1

UniProtKB/TrEMBL

Q96BA2