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    SH3RF3 SH3 domain containing ring finger 3 [ Homo sapiens (human) ]

    Gene ID: 344558, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SH3RF3provided by HGNC
    Official Full Name
    SH3 domain containing ring finger 3provided by HGNC
    Primary source
    HGNC:HGNC:24699
    See related
    Ensembl:ENSG00000172985 MIM:618933; AllianceGenome:HGNC:24699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    POSH2; SH3MD4
    Summary
    Enables ubiquitin protein ligase activity. Involved in positive regulation of JNK cascade and protein autoubiquitination. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 1.9), gall bladder (RPKM 1.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SH3RF3 in Genome Data Viewer
    Location:
    2q13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (109129205..109504634)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (109589723..109965692)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (109745661..110262211)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RAN binding protein 2 Neighboring gene coiled-coil domain containing 138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109526299-109526800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109545693-109546192 Neighboring gene ribosomal protein L39 pseudogene 16 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:109573418-109574617 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:109588237-109589436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109589833-109590332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109604149-109604650 Neighboring gene ectodysplasin A receptor Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:109636621-109637336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:109663535-109664035 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:109685726-109686670 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:109705183-109705390 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:109719016-109719749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11857 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11858 Neighboring gene SH3RF3 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:109793904-109794078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16355 Neighboring gene microRNA 4265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11859 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16361 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16359 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:109876451-109876952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:109876953-109877452 Neighboring gene Sharpr-MPRA regulatory region 14332 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:109891529-109891729 Neighboring gene Sharpr-MPRA regulatory region 6940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:109933325-109934314 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:109934315-109935303 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 9 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:109964015-109964260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16362 Neighboring gene microRNA 4266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110012695-110013196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110013197-110013696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110031578-110032191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110032192-110032804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110046278-110046841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110063255-110063754 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:110065234-110065738 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16365 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110275114-110275653 Neighboring gene Sharpr-MPRA regulatory region 2497 Neighboring gene MPRA-validated peak3814 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:110352345-110352845 Neighboring gene septin 10 Neighboring gene ribosomal protein L37 pseudogene 12 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:110370433-110371342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11861 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11862 Neighboring gene sosondowah ankyrin repeat domain family member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MiR-192-5p inhibits proliferation, migration, and invasion in papillary thyroid carcinoma cells by regulation of SH3RF3. Fu S, et al. Biosci Rep, 2021 Sep 30. PMID 34486645, Free PMC Article
    2. POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain. Kärkkäinen S, et al. FEBS Lett, 2010 Sep 24. PMID 20696164
    3. SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation. Zhang P, et al. Nat Commun, 2020 May 19. PMID 32427938, Free PMC Article
    4. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Ma B, et al. Nat Cell Biol, 2015 Jan. PMID 25438054
    5. Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome. Kärkkäinen S, et al. EMBO Rep, 2006 Feb. PMID 16374509, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-192-5p inhibits proliferation, migration, and invasion in papillary thyroid carcinoma cells by regulation of SH3RF3.
      Title: MiR-192-5p inhibits proliferation, migration, and invasion in papillary thyroid carcinoma cells by regulation of SH3RF3.
    2. SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation.
      Title: SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation.
    3. POSH2 was found to have a conserved N-terminal extension not present in POSH1 and POSH3. POSH2 has GTP-loaded Rac1 binding activity and this activity was mapped to a partial Cdc42/Rac-interactive binding (CRIB) domain.
      Title: POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00204

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autoubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase SH3RF3
    Names
    SH3 domain-containing RING finger protein 3
    SH3 multiple domains 4
    plenty of SH3s-2
    NP_001092759.1
    XP_011509411.1
    XP_011509412.1
    XP_047300100.1
    XP_054197741.1
    XP_054197742.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099289.3 → NP_001092759.1  E3 ubiquitin-protein ligase SH3RF3

      See identical proteins and their annotated locations for NP_001092759.1

      Status: VALIDATED

      Source sequence(s)
      AA916456, AC133109, AK074131, DQ307286, DV080665, HY224642
      Consensus CDS
      CCDS74557.1
      UniProtKB/Swiss-Prot
      A0SDZ7, A8MPR1, Q8NDU1, Q8TEJ3
      Related
      ENSP00000309186.6, ENST00000309415.8
      Conserved Domains (5) summary
      cd11785
      Location:827 → 881
      SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
      cd11925
      Location:467 → 523
      SH3_SH3RF3_3; Third Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
      cd11928
      Location:197 → 250
      SH3_SH3RF3_1; First Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
      cd11931
      Location:260 → 314
      SH3_SH3RF3_2; Second Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
      cd00162
      Location:56 → 98
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      109129205..109504634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511109.3 → XP_011509411.1  E3 ubiquitin-protein ligase SH3RF3 isoform X1

      Conserved Domains (5) summary
      cd11925
      Location:467 → 523
      SH3_SH3RF3_3; Third Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
      cd11928
      Location:197 → 250
      SH3_SH3RF3_1; First Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
      cd11931
      Location:260 → 314
      SH3_SH3RF3_2; Second Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
      PLN02217
      Location:516 → 649
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      cd16750
      Location:53 → 98
      RING-HC_SH3RF3; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 3 (SH3RF3) and similar proteins

    2. XM_047444144.1 → XP_047300100.1  E3 ubiquitin-protein ligase SH3RF3 isoform X2

    3. XM_011511110.3 → XP_011509412.1  E3 ubiquitin-protein ligase SH3RF3 isoform X3

      Conserved Domains (3) summary
      cd11785
      Location:502 → 556
      SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
      cd11925
      Location:142 → 198
      SH3_SH3RF3_3; Third Src Homology 3 domain of SH3 domain containing ring finger 3, an E3 ubiquitin-protein ligase
      PLN02217
      Location:191 → 324
      PLN02217; probable pectinesterase/pectinesterase inhibitor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      109589723..109965692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341766.1 → XP_054197741.1  E3 ubiquitin-protein ligase SH3RF3 isoform X2

    2. XM_054341767.1 → XP_054197742.1  E3 ubiquitin-protein ligase SH3RF3 isoform X3

    RNA

    1. XR_008486359.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TEJ3.2 GenPept UniProtKB/Swiss-Prot:Q8TEJ3

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