GRSF1 G-rich RNA sequence binding factor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GRSF1provided by HGNC
Official Full Name: G-rich RNA sequence binding factor 1provided by HGNC
Primary source: HGNC:HGNC:4610
See related: Ensembl:ENSG00000132463 MIM:604851; AllianceGenome:HGNC:4610
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in adrenal (RPKM 14.1), brain (RPKM 13.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q13.3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (70815783..70843235, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (74158253..74185655, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (71681500..71705607, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRSF1 deficiency attenuates mitochondrial function in aging granulosa cells.
Title: GRSF1 deficiency attenuates mitochondrial function in aging granulosa cells.
GRSF1 antagonizes age-associated hypercoagulability via modulation of fibrinogen mRNA stability.
Title: GRSF1 antagonizes age-associated hypercoagulability via modulation of fibrinogen mRNA stability.
GRSF1 promotes tumorigenesis and EMT-mediated metastasis through PI3K/AKT pathway in gastric cancer.
Title: GRSF1 promotes tumorigenesis and EMT-mediated metastasis through PI3K/AKT pathway in gastric cancer.
Identification of the COMM-domain containing protein 1 as specific binding partner for the guanine-rich RNA sequence binding factor 1.
Title: Identification of the COMM-domain containing protein 1 as specific binding partner for the guanine-rich RNA sequence binding factor 1.
GRSF1 is an age-related regulator of senescence.
Title: GRSF1 is an age-related regulator of senescence.
A novel miRNA identified in GRSF1 complex drives the metastasis via the PIK3R3/AKT/NF-kappaB and TIMP3/MMP9 pathways in cervical cancer cells.
Title: A novel miRNA identified in GRSF1 complex drives the metastasis via the PIK3R3/AKT/NF-κB and TIMP3/MMP9 pathways in cervical cancer cells.
our results indicate that GRSF1 helps preserve mitochondrial homeostasis, in turn preventing oxidative DNA damage and the activation of mTOR and NF-kappaB, and suppressing a transcriptional pro-inflammatory program leading to increased IL6 production.
Title: Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program.
These findings suggest that Twinkle is essential for RNA organization in granules, and that mtSSB is involved in the recently proposed GRSF1-mtRNA degradosome pathway, a route suggested to be particularly aimed at degradation of G-quadruplex prone long non-coding mtRNAs.
Title: Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB.
These findings indicate that the decline in GRSF1 levels during cellular senescence contributes to impairing mitochondrial function, elevating ROS and DNA damage, suppressing growth, and implementing a pro-inflammatory program.
Title: GRSF1 suppresses cell senescence.
GRSF1 positively regulates degradosome-dependent decay of non-coding mitochondrial transcripts that form G4 structures. Comprehensive molecular analyses revealed that GRSF1 melts G4 RNA structures in mtRNAs, which facilitates their degradation by the hSuv3-PNPase complex both in vitro and in vivo.
Title: Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-68211 (e-PCR)
- UniSTS:9490

GDB:434012 (e-PCR)
- UniSTS:157204

D10S275 (e-PCR)
- UniSTS:147992

SHGC-50636 (e-PCR)
- UniSTS:2622

RH17982 (e-PCR)
- UniSTS:42860

D1S1423 (e-PCR)
- UniSTS:149619

D4S2668 (e-PCR)
- UniSTS:69831

D5S1597E (e-PCR)
- UniSTS:151019

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G-quadruplex RNA binding	TAS Traceable Author Statement more info
enables RNA binding	HDA more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial RNA catabolic process	TAS Traceable Author Statement more info
involved_in morphogenesis of embryonic epithelium	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial RNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	TAS Traceable Author Statement more info
located_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HTP more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: G-rich sequence factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098477.2 → NP_001091947.1 G-rich sequence factor 1 isoform 2

See identical proteins and their annotated locations for NP_001091947.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC021989

Consensus CDS

CCDS47070.1

UniProtKB/TrEMBL

B7Z2D8

Related

ENSP00000425430.1, ENST00000502323.5

Conserved Domains (3) summary

cd12505
Location:87 → 160

RRM2_GRSF1; RNA recognition motif 2 in G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12733
Location:239 → 313

RRM3_GRSF1; RNA recognition motif 3 in G-rich sequence factor 1 (GRSF-1) and similar proteins

cl17169
Location:1 → 65

RRM_SF; RNA recognition motif (RRM) superfamily
NM_002092.4 → NP_002083.4 G-rich sequence factor 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC021989

Consensus CDS

CCDS47069.1

UniProtKB/Swiss-Prot

B3KPW0, Q12849, Q4W5S5, Q6ZST3, Q8IWD6, Q8NBD2

UniProtKB/TrEMBL

B3KW50

Related

ENSP00000254799.6, ENST00000254799.11

Conserved Domains (4) summary

COG0724
Location:307 → 459

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12505
Location:249 → 322

RRM2_GRSF1; RNA recognition motif 2 in G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12730
Location:149 → 227

RRM1_GRSF1; RNA recognition motif 1 in G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12733
Location:401 → 475

RRM3_GRSF1; RNA recognition motif 3 in G-rich sequence factor 1 (GRSF-1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

70815783..70843235 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011531897.4 → XP_011530199.1 G-rich sequence factor 1 isoform X2

See identical proteins and their annotated locations for XP_011530199.1

UniProtKB/TrEMBL

B7Z2D8

Conserved Domains (3) summary

cd12505
Location:87 → 160

RRM2_GRSF1; RNA recognition motif 2 in G-rich sequence factor 1 (GRSF-1) and similar proteins

cd12733
Location:239 → 313

RRM3_GRSF1; RNA recognition motif 3 in G-rich sequence factor 1 (GRSF-1) and similar proteins

cl17169
Location:1 → 65

RRM_SF; RNA recognition motif (RRM) superfamily
XM_047450140.1 → XP_047306096.1 G-rich sequence factor 1 isoform X1

Related

ENSP00000421789.1, ENST00000514161.5