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    TTC33 tetratricopeptide repeat domain 33 [ Homo sapiens (human) ]

    Gene ID: 23548, updated on 27-Nov-2024

    Summary

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    Official Symbol
    TTC33provided by HGNC
    Official Full Name
    tetratricopeptide repeat domain 33provided by HGNC
    Primary source
    HGNC:HGNC:29959
    See related
    Ensembl:ENSG00000113638 AllianceGenome:HGNC:29959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OSRF
    Expression
    Ubiquitous expression in brain (RPKM 7.4), thyroid (RPKM 4.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TTC33 in Genome Data Viewer
    Location:
    5p13.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (40711576..40755961, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (40967941..41012360, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (40711678..40756063, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374737 Neighboring gene small nucleolar RNA SNORA63 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15982 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:40681035-40681562 Neighboring gene prostaglandin E receptor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22503 Neighboring gene uncharacterized LOC124900968 Neighboring gene protein kinase AMP-activated catalytic subunit alpha 1 Neighboring gene HNF1 motif-containing MPRA enhancer 12 Neighboring gene small nucleolar RNA SNORA57

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924
    2. New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing. Basei FL, et al. Proteome Sci, 2015. PMID 25798074, Free PMC Article
    3. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. Yadav L, et al. Cell Syst, 2017 Apr 26. PMID 28330616
    4. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. St-Denis N, et al. Cell Rep, 2016 Nov 22. PMID 27880917
    5. PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα. Ramberger E, et al. iScience, 2021 Jun 25. PMID 34189442, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 33
    Names
    TPR repeat protein 33
    osmosis responsive factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012382.3 → NP_036514.1  tetratricopeptide repeat protein 33

      See identical proteins and their annotated locations for NP_036514.1

      Status: VALIDATED

      Source sequence(s)
      AC093264, AI174764, BC015701, BC036536, BE869916, BF509085, BM543635, BM689740, BQ922097, CR738110, DA518274, DA652008
      Consensus CDS
      CCDS3931.1
      UniProtKB/Swiss-Prot
      B2R6G0, O95105, Q6PID6
      Related
      ENSP00000338533.4, ENST00000337702.5
      Conserved Domains (2) summary
      sd00006
      Location:59 → 87
      TPR; TPR repeat [structural motif]
      cl27017
      Location:71 → 192
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      40711576..40755961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514003.4 → XP_011512305.1  tetratricopeptide repeat protein 33 isoform X1

      See identical proteins and their annotated locations for XP_011512305.1

      UniProtKB/Swiss-Prot
      B2R6G0, O95105, Q6PID6
      Conserved Domains (2) summary
      sd00006
      Location:59 → 87
      TPR; TPR repeat [structural motif]
      cl27017
      Location:71 → 192
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      40967941..41012360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352255.1 → XP_054208230.1  tetratricopeptide repeat protein 33 isoform X1

      UniProtKB/Swiss-Prot
      B2R6G0, O95105, Q6PID6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PID6.2 GenPept UniProtKB/Swiss-Prot:Q6PID6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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