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    SENP1 SUMO specific peptidase 1 [ Homo sapiens (human) ]

    Gene ID: 29843, updated on 10-Dec-2024

    Summary

    Official Symbol
    SENP1provided by HGNC
    Official Full Name
    SUMO specific peptidase 1provided by HGNC
    Primary source
    HGNC:HGNC:17927
    See related
    Ensembl:ENSG00000079387 MIM:612157; AllianceGenome:HGNC:17927
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SuPr-2
    Summary
    This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
    Expression
    Broad expression in testis (RPKM 36.5), lymph node (RPKM 5.6) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SENP1 in Genome Data Viewer
    Location:
    12q13.11
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48042897..48106079, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48004645..48067418, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48436680..48499862, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48375074-48375619 Neighboring gene collagen type II alpha 1 chain Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6277 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48404129-48404630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:48404631-48405130 Neighboring gene uncharacterized LOC105369750 Neighboring gene uncharacterized LOC124902927 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:48415301-48416292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:48431351-48432291 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:48439137-48440336 Neighboring gene ribosomal protein L37 pseudogene 19 Neighboring gene V-type proton ATPase subunit F-like Neighboring gene RNA, U6 small nuclear 1203, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr12:48484832-48485048 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48498859-48499734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48499735-48500608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6279 Neighboring gene phosphofructokinase, muscle Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:48536214-48537195 Neighboring gene microRNA 6505 Neighboring gene NANOG hESC enhancer GRCh37_chr12:48551082-48551604 Neighboring gene ankyrin repeat and SOCS box containing 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables SUMO-specific endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables deSUMOylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables deSUMOylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables endopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    sentrin-specific protease 1
    Names
    SUMO1/sentrin specific peptidase 1
    SUMO1/sentrin specific protease 1
    sentrin/SUMO-specific protease SENP1
    NP_001254523.1
    NP_001254524.1
    XP_006719424.1
    XP_011536546.1
    XP_011536547.1
    XP_016874718.1
    XP_016874719.1
    XP_016874720.1
    XP_016874721.1
    XP_016874722.1
    XP_016874723.1
    XP_016874724.1
    XP_016874726.1
    XP_047284708.1
    XP_054227853.1
    XP_054227854.1
    XP_054227855.1
    XP_054227856.1
    XP_054227857.1
    XP_054227858.1
    XP_054227859.1
    XP_054227860.1
    XP_054227861.1
    XP_054227862.1
    XP_054227863.1
    XP_054227864.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267594.2NP_001254523.1  sentrin-specific protease 1

      See identical proteins and their annotated locations for NP_001254523.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the functional protein. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC004801, AK312874, BX640784
      Consensus CDS
      CCDS44868.2
      UniProtKB/Swiss-Prot
      A8K7P5, Q86XC8, Q9P0U3
      Related
      ENSP00000447328.1, ENST00000549518.6
      Conserved Domains (1) summary
      cl23802
      Location:420642
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    2. NM_001267595.2NP_001254524.1  sentrin-specific protease 1

      See identical proteins and their annotated locations for NP_001254524.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC004801, BC045639, BX537920, BX640784
      Consensus CDS
      CCDS44868.2
      UniProtKB/Swiss-Prot
      A8K7P5, Q86XC8, Q9P0U3
      Related
      ENSP00000394791.2, ENST00000448372.6
      Conserved Domains (1) summary
      cl23802
      Location:420642
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RNA

    1. NR_051991.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC004801, BX537920, BX640784
      Related
      ENST00000552189.5
    2. NR_051992.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC004801, BX537920, BX640784

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      48042897..48106079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019237.2XP_016874726.1  sentrin-specific protease 1 isoform X9

    2. XM_017019235.2XP_016874724.1  sentrin-specific protease 1 isoform X8

    3. XM_017019232.2XP_016874721.1  sentrin-specific protease 1 isoform X4

    4. XM_047428752.1XP_047284708.1  sentrin-specific protease 1 isoform X7

    5. XM_011538245.4XP_011536547.1  sentrin-specific protease 1 isoform X6

      Conserved Domains (1) summary
      cl23802
      Location:436658
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    6. XM_011538244.4XP_011536546.1  sentrin-specific protease 1 isoform X5

      Conserved Domains (1) summary
      cl23802
      Location:439661
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    7. XM_006719361.4XP_006719424.1  sentrin-specific protease 1 isoform X3

      See identical proteins and their annotated locations for XP_006719424.1

      Conserved Domains (1) summary
      cl23802
      Location:452674
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
    8. XM_017019233.3XP_016874722.1  sentrin-specific protease 1 isoform X8

    9. XM_017019230.3XP_016874719.1  sentrin-specific protease 1 isoform X2

    10. XM_017019229.3XP_016874718.1  sentrin-specific protease 1 isoform X1

    11. XM_017019234.3XP_016874723.1  sentrin-specific protease 1 isoform X8

    12. XM_017019231.3XP_016874720.1  sentrin-specific protease 1 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      48004645..48067418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371889.1XP_054227864.1  sentrin-specific protease 1 isoform X9

    2. XM_054371887.1XP_054227862.1  sentrin-specific protease 1 isoform X8

    3. XM_054371881.1XP_054227856.1  sentrin-specific protease 1 isoform X4

    4. XM_054371885.1XP_054227860.1  sentrin-specific protease 1 isoform X7

    5. XM_054371884.1XP_054227859.1  sentrin-specific protease 1 isoform X6

    6. XM_054371883.1XP_054227858.1  sentrin-specific protease 1 isoform X5

    7. XM_054371880.1XP_054227855.1  sentrin-specific protease 1 isoform X3

    8. XM_054371888.1XP_054227863.1  sentrin-specific protease 1 isoform X8

    9. XM_054371879.1XP_054227854.1  sentrin-specific protease 1 isoform X2

    10. XM_054371878.1XP_054227853.1  sentrin-specific protease 1 isoform X1

    11. XM_054371886.1XP_054227861.1  sentrin-specific protease 1 isoform X8

    12. XM_054371882.1XP_054227857.1  sentrin-specific protease 1 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014554.2: Suppressed sequence

      Description
      NM_014554.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.