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    ANP32A acidic nuclear phosphoprotein 32 family member A [ Homo sapiens (human) ]

    Gene ID: 8125, updated on 10-Dec-2024

    Summary

    Official Symbol
    ANP32Aprovided by HGNC
    Official Full Name
    acidic nuclear phosphoprotein 32 family member Aprovided by HGNC
    Primary source
    HGNC:HGNC:13233
    See related
    Ensembl:ENSG00000140350 MIM:600832; AllianceGenome:HGNC:13233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LANP; MAPM; PP32; HPPCn; PHAP1; PHAPI; I1PP2A; C15orf1
    Summary
    Enables RNA binding activity. Involved in nucleocytoplasmic transport. Located in endoplasmic reticulum; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 45.8), bone marrow (RPKM 40.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ANP32A in Genome Data Viewer
    Location:
    15q23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (68778535..68820895, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (66601108..66643452, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69070874..69113234, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene coronin 2B Neighboring gene uncharacterized LOC124903514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68943583-68944150 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr15:68944208-68944708 Neighboring gene Sharpr-MPRA regulatory region 8573 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:68961677-68962176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68966278-68966778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68987247-68987836 Neighboring gene heart enhancer 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6588 Neighboring gene cysteinyl-tRNA synthetase 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69080134-69080641 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69083767-69084268 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69084269-69084768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69087559-69088131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69103956-69104456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9651 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69109604-69110186 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69111351-69111932 Neighboring gene ANP32A intronic transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6591 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6590 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69111933-69112514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6593 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6594 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6595 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:69115796-69116596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9652 Neighboring gene microRNA 4312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9653 Neighboring gene cytokine induced apoptosis inhibitor 1 pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69167471-69168078 Neighboring gene MPRA-validated peak2374 silencer Neighboring gene SPESP1-NOX5 readthrough Neighboring gene sperm equatorial segment protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev The interaction of Rev with ANP32A is decreased by the presence of RRE PubMed
    rev HIV-1 Rev interacting protein, acidic (leucine-rich) nuclear phosphoprotein 32 family, member A (ANP32A), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC119787, MGC150373

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in nucleocytoplasmic transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nucleocytoplasmic transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    acidic leucine-rich nuclear phosphoprotein 32 family member A
    Names
    acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
    acidic nuclear phosphoprotein pp32
    cerebellar leucine rich acidic nuclear protein
    epididymis secretory sperm binding protein
    hepatopoietin Cn
    inhibitor-1 of protein phosphatase-2A
    leucine-rich acidic nuclear protein
    mapmodulin
    potent heat-stable protein phosphatase 2A inhibitor I1PP2A
    putative HLA-DR-associated protein I
    putative human HLA class II associated protein I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006305.4NP_006296.1  acidic leucine-rich nuclear phosphoprotein 32 family member A

      See identical proteins and their annotated locations for NP_006296.1

      Status: VALIDATED

      Source sequence(s)
      BC007200, BC064969, DA825897
      Consensus CDS
      CCDS45292.1
      UniProtKB/Swiss-Prot
      B2R6T4, P39687, Q53FK4, Q5J8L8, Q7M4N6
      UniProtKB/TrEMBL
      A0A384P5U2
      Related
      ENSP00000417864.2, ENST00000465139.6
      Conserved Domains (2) summary
      sd00033
      Location:90114
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:71146
      LRR_9; Leucine-rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      68778535..68820895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      66601108..66643452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)