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    GLI3 GLI family zinc finger 3 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 463369, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GLI3provided by VGNC
    Official Full Name
    GLI family zinc finger 3provided by VGNC
    Primary source
    VGNC:VGNC:4376
    Locus tag
    CK820_G0040402
    See related
    Ensembl:ENSPTRG00000019117
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Also known as
    GLI3FL; GLI3-190
    Orthologs
    human mouse all
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    Genomic context

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    See GLI3 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 6 NC_072404.2 (47151497..47427054)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 7 NC_072405.1 (44792734..45068026)

    Chromosome 6 - NC_072404.2Genomic Context describing neighboring genes Neighboring gene T-complex protein 1 subunit alpha-like Neighboring gene uncharacterized LOC107971516 Neighboring gene uncharacterized LOC134810531 Neighboring gene uncharacterized LOC104007196 Neighboring gene inhibin subunit beta A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Accelerated evolution of nervous system genes in the origin of Homo sapiens. Dorus S, et al. Cell, 2004 Dec 29. PMID 15620360
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcriptional activator GLI3
    Names
    GLI-Kruppel family member 3
    GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome)
    GLI3 form of 190 kDa
    GLI3 full length protein
    zinc finger protein GLI3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034190.1 → NP_001029362.1  transcriptional activator GLI3

      See identical proteins and their annotated locations for NP_001029362.1

      Status: PROVISIONAL

      Source sequence(s)
      AY665272
      UniProtKB/Swiss-Prot
      Q5IS56
      UniProtKB/TrEMBL
      K7C5V6
      Conserved Domains (2) summary
      sd00017
      Location:548 → 570
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:562 → 589
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072404.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      47151497..47427054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009452941.5 → XP_009451216.1  transcriptional activator GLI3 isoform X1

      See identical proteins and their annotated locations for XP_009451216.1

      UniProtKB/TrEMBL
      A0A2J8K9K4, A0A6D2WTC0, H2QUH1
      Related
      ENSPTRP00000032656.3
      Conserved Domains (2) summary
      COG5189
      Location:542 → 632
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:548 → 570
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_063813784.1 → XP_063669854.1  transcriptional activator GLI3 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5IS56.1 GenPept UniProtKB/Swiss-Prot:Q5IS56

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